Benzathine benzylpenicillin is a Medicine belongs to PENICILLINS group whose information about Brand can be referenced from   Book : Martindale    Page : 228   Edition : 38,

  ►   Brandname : Longacillin,Pencom,Pendysin,Bicillin L-A

  ►  Strength : Injection with 0.6   million units, Injection with 1.2  million units, Injection with 2.4  million units, Oral Suspension with   , Tablet with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 807   Edition : 12, Martindale    Page : 228   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM,
Reference :-   Book : Martindale    Page : 227   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Early syphilis IM 1.8 gm Injection a single dose given as 2 (deep i.m) injections at separate sites.
2 Late syphilis IM 1.8 gm Injection It is given at weekly intervals for 3 consecutive weeks.
3 Treatment of yaws, pinta and endemic syphilis IM 900 mg Injection a single dose given
4 Streptococcal pharyngitis IM 900 mg Injection a single dose given
5 Primary prevention of rheumatic fever IM 900 mg Injection a single dose given
6 To prevent recurrences of acute rheumatic fever IM 900 mg Injection given every 3 or 4 weeks.

Ref :-  Book : Martindale    Page : 227   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Streptococcal pharyngitis 37.5 mg/kg Injection
2 Streptococcal pharyngitis less than 27 kg 225 450 mg Injection
3 Streptococcal pharyngitis 27 kg or more 675 mg Injection
4 Congenital syphilis IM 37.5 mg/kg Injection
5 Treatment of yaws, pinta and endemic syphilis 450 mg
6 To prevent recurrences of acute rheumatic fever less than 27 kg 450 mg
7 To prevent recurrences of acute rheumatic fever more than 27 kg 900 mg

Ref :- Book : Martindale    Page : 227   Edition : 38,
►  Side Effect : hypersensitivity reactions, Skin rashes, anaphylaxis, diarrhea, nausea, sore mouth, Pseudomembranous colitis, haemolytic anaemia, neutropenia, prolongation of bleeding time, defective platelet function, convulsion, encephalopathy, electrolyte disturbances, black hairy tongue, Nephropathy, interstitial nephritis, Jarisch-Herxheimer reaction, ,
Ref :-   Book : Martindale    Page : 227, 229   Edition : 38, Martindale    Page : 227,229   Edition : 38,    Page :    Edition : ,

►  Drug Interaction : Drug interaction of Benzathine benzylpenicillin is with ,  Probenecid , Chloramphenicol ,
Ref :-   Book : Martindale    Page : 227,230   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Probenecid prolongs the half-life of benzathine benzylpenicillin by competing with it for renal tubular secretion and may be used therapeutically for this purpose. Benzathine benzylpenicillin may also interact with some bacteriostatic drugs, such as chloramphenicol or tetracyclines. ,
Ref :-   Book : Martindale    Page : 227,230   Edition : 38,


►  Contraindication : i.v route, intrathecal route, Skin contact, hypersensitive to penicillins,
Ref :-   Book : Martindale    Page : 227,230   Edition : 38,
  ►  Mechanism of Action :   Benzathine benzylpenicillin inhibits the bacterial growth by interfearing with the transpeptidation reaction of bacterial cell wall synthesis. Benzathine benzylpenicillin is a structural analog of the natural D-Ala-D-Ala substrate, covalently bind to the active site of PBPs. This inhibits the transpeptidation reaction, halting peptidoglycan synthesis, and the cell dies. ,
Ref :-   Book : Basic & Clinical pharmacology    Page : 792   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Black Bean with Another pathway,

  ►  Pathway with its reference as follows :-
  • Cycloeudesmol Aerropysinl have Antibiotic effect --- (Duke, J. & Duke, J. (2002). Handbook of medicinal herbs. Boca Raton, FL: CRC Press. )

  •   ►  URL -- https://books.google.co.in/books?id=B_XLBQAAQBAJ&pg=PA822&dq=Handbook+of+medicinal+herbs&hl=en&sa=X&redir_esc=y#v=onepage&q=Handbook%20of%20medicinal%20herbs&f=false,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- PHYLLIUM with Make antibiotic less effective .,

      ►  Reference :-
  • PDR for Herbal medicines. (2000) (4th ed.). U.S.

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 227   Edition : 38,


    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   24 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 227   Edition : 38,