Benznidazole is a Medicine belongs to Antiprotozoals group whose information about Brand can be referenced from   Book :

  ►   Brandname : NA

  ►  Strength :

A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 917   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 American trypanosomiasis (Chagas’ disease) Oral 5 7 mg/kg Given during the early acute stage of the disease. Given daily in two divided doses usually for 60 days.

Ref :-  Book : Martindale    Page : 917   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 American trypanosomiasis (Chagas’ disease) Oral 10 mg/kg

Ref :- Book : Martindale    Page : 917   Edition : 37,
►  Side Effect : hypersensitivity reactions, fever, lymphadenopathy, joint pains, muscle pain, bone marrow depression, thrombocytopenic purpura, agranulocytosis, generalized odema, polyneuropathy, paraesthesia, peripheral neuropathy, dermatitis,
Ref :-   Book : Martindale    Page : 917   Edition : 37,

►  Drug Interaction : Drug interaction of Benznidazole is with NA

  ►    Mechanism of Drug Drug Interaction :  Patients are advised not to drink alcoholic beverages while taking benznidazole.,
Ref :-   Book : Martindale    Page : 917   Edition : 37,


►  Contraindication : pregnancy,
Ref :-   Book : Martindale    Page : 917   Edition : 37,
  ►  Mechanism of Action :   Both nifurtimox and benznidazole are activated by a NADH- dependent mitochondrial nitroreductase , leading to the intracellular generation of nitro radical anions that are thought to account for the trypanocidal effect .the generated nitro anion radical from covalent attachments to macromolecules leading to cellular damage that kills the parasites. ,
Ref :-   Book : Goodman    Page : 1432   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Curcumin with Another pathway,

  ►  Pathway with its reference as follows :-
  • antiparasitic --- ( Mallo, N., DeFelipe, A., Folgueira, I., Sueiro, R., Lamas, J., & Leiro, J. (2016). Combined antiparasitic and anti-inflammatory effects of the natural polyphenol curcumin on turbot scuticociliatosis. )

  •   ►  URL -- http://onlinelibrary.wiley.com/doi/10.1111/jfd.12503/abstract,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   NA


    ►    Plasma Half-life :
      Min value :-   12 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 917   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 917   Edition : 37,