Benzthiazide is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1316   Edition : 38  

  ►   Brandname : Ditide
  ►  Strength :

A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 1348   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Oedema Oral 75 mg Given daily.

Ref :-  Book : Martindale    Page : 1348   Edition : 37  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Dry mouth, Thirst, Weakness, Lethargy, Drowsiness, Restlessness, Muscle pain, Muscle cramps, Seizure, Oliguria, Hypotension, Gastrointestinal disturbance, Anorexia, Gastric irritation, Nausea, Vomiting, Constipation, Diarrhea, Sialadenitis, Headache, Dizziness, Paraesthesia, impotence, Yellow vision, Hypersenstivity, Skin rashes, Fever, Pulmonary oedema, Pneumonitis, Anaphylaxis, Toxic epidermal necrolysis, Cholestatic jaundice, Pancreatitis, Blood dyscrasias, Thrombocytopenia, Photosensitivity reactions
Ref :-   Book : Martindale    Page : 1438   Edition : 37.  

►  Drug Interaction : Drug interaction of Benzthiazide is with Competitive neuromuscular blockers, Beta 2 Agonist, Alpha blocker, Angiotensin converting enzyme inhibitor, NONSTEROIDAL ANTI-INFLAMMATORY DRUGS, , TETRACYCLINES , ,  Digitalis, Astemizole, Terfenadine, Halofantrine, Pimozide , Sotalol , Corticosteroids, Carbenoxolone, Corticotropin , Lithium carbonate , Allopurinol
Ref :-   Book : Martindale    Page : 1406   Edition : 38.  

  ►    Mechanism of Drug Drug Interaction :  Many of the interactions of hydrochlorothiazide and other thiazides are due to their effects on fluid and electrolyte balance. Diuretic-induced hypokalaemia may enhance the toxicity of digitalis glycosides and may also increase the risk of arrhythmias with drugs that prolong the QT interval, such as astemizole, terfenadine, halofantrine, pimozide, and sotalol. Thiazides may enhance the neuromuscular blocking action of competitive neuromuscular blockers, such as atracurium, probably by their hypokalaemic effect. The potassium- depleting effect of diuretics may be enhanced by corticosteroids, corticotropin, beta2 agonists such as salbutamol, carbenoxolone, amphotericin B, or reboxetine. Diuretics may enhance the effect of other antihypertensives, particularly the first-dose hypotension that occurs with alpha blockers or ACE inhibitors. The antihypertensive effects of diuretics may be antagonised by drugs that cause fluid retention, such as corticosteroids, NSAIDs, or carbenoxolone; the nephrotoxicity of NSAIDs may enhanced. Thiazides should not usually be used with lithium since the association may lead to toxic blood concentrations of lithium. Other drugs for which increased toxicity has been reported when given with thiazides include allopurinol and tetracyclines. Thiazides may alter the requirements for hypoglycaemics in diabetic patients.
Ref :-   Book : Martindale    Page : 1406   Edition : 38.  

►  Contraindication : Severe hepatic impairment, Addison’s disease , Preexisting hypercalcaemia
Ref :-   Book : Martindale    Page : 1316,1406   Edition : 38.  
  ►  Mechanism of Action :   Thiazides are moderately potent diuretics and exert their diuretic effect by reducing the reabsorption of electrolytes from the renal tubules, thereby increasing the excretion of sodium and chloride ions, and consequently of water. They act mainly at the beginning of the distal tubules. The excretion of other electrolytes, notably potassium and magnesium, is also increased. The excretion of calcium is reduced.
Ref :-   Book : Martindale    Page : 1316,1403   Edition : 38.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- Cucumber with Another pathway.   Watermelon with Another pathway.   Celery with Another pathway.  

  ►  Pathway with its reference as follows :-
  • high water content --- ( gur, Somia. "Watermelon As Diurtic ;As In Vivo Investigation On Mice .". American J ournal of Drug Delivery and Therapeutics (2016): n. pag. Print. )
  • high water content --- ( Rani, Bina. "Invigorating Efficacy Of Cucumis Sativa On Health Care & Radiance .". International Journal of Chemistry & Pharmacutical Science . 2.3 (2014): 734 -744. Print. )
  • high water content --- (Moghadam, Maryam. "Antihypertensive Effect Of Celery Seed On Rat Blood Pressure In Chronic Administration". Journal of Medicinal Food 16.6 (2013): 558-563. Web. 29 Oct. 2016. )

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  • DIETARY Substance Interactions

    ​   ► This Medicine interact with :- POTASSIUM with Increase in Nutrient Level.   MAGNESIUM with Increase in Nutrient Level.  

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL --

    ContraIndication DIETARY Substance

    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   NA

    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA