Benzylpenicillin is a Medicine belongs to PENICILLINS group whose information about Brand can be referenced from   Book : Martindale    Page : 230   Edition : 38,

  ►   Brandname : Pencip,Pentids,Pfizerpen,Crystapen,Benpen,Infectocillin

  ►  Strength : Injection with 1million  units, Injection with 2 million  units, Injection with 3 million  units, Injection with 5 million  units, Injection with 10 million  units, Injection with 20 million  units, Capsule with   , Oral solution with   , Tablet with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 807   Edition : 12, Martindale    Page : 230   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IM, IV, Oral,
Reference :-   Book : Martindale    Page : 228   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Endocarditis IV 1.2 gm Injection given every 4 hours along with an aminoglycoside.
2 Meningococcal meningitis IV 2.4 18 gm Injection given every 4 hours.
3 Pneumococcal meningitis IV 2.4 gm Injection given every 4 hours.
4 Suspected meningococcal infection IM or IV 1.2 gm Injection given before transfer to hospital.
5 Intrapartum prophylaxis against group B streptococcal infection IV 3 gm Injection Given as a single dose; than 1.5 g every 4 hours until delivery.

Ref :-  Book : Martindale    Page : 228, 229   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Mild to moderate infections under 7 Days i.m or i.v 25 mg/kg Injection b.d/t.i.d
2 Mild to moderate infections 7 Day 28 Day i.m or i.v 25 mg/kg Injection t.i.d.
3 Mild to moderate infections From 1 Month i.m or i.v 25 mg/kg Injection q.i.d.
4 Endocarditis From 1 Month IV 25 mg/kg Injection
5 Meningitis and meningococcal disease less than 7 Days IV 50 mg/kg Injection b.d.
6 Meningitis and meningococcal disease 7 Day 28 Day IV 50 mg/kg Injection t.i.d.
7 Meningitis and meningococcal disease From 1 Month IV 50 mg/kg Injection
8 Suspected meningococcal infection under 1 year 300 mg Injection
9 Suspected meningococcal infection 1 Year 9 Year 600 mg Injection
10 Suspected meningococcal infection From 10 Year 1.2 gm Injection

Ref :- Book : Martindale    Page : 229   Edition : 38,
►  Side Effect : diarrhea, nausea, hypersensitivity reactions, allergic reactions, Skin rashes, sore mouth, sore tongue, black hairy tongue, Pseudomembranous colitis, haemolytic anaemia, neutropenia, prolongation of bleeding time, defective platelet function, convulsion, encephalopathy, electrolyte disturbances, Nephropathy, interstitial nephritis, , occasional anaphylaxis, Jarisch-Herxheimer reaction,
Ref :-   Book : Martindale    Page : 229   Edition : 38,    Page :    Edition : ,

►  Drug Interaction : Drug interaction of Benzylpenicillin is with TETRACYCLINES ,  Probenecid , Chloramphenicol ,
Ref :-   Book : Martindale    Page : 229   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Probenecid prolongs the half-life of benzathine benzylpenicillin by competing with it for renal tubular secretion and may be used therapeutically for this purpose. Benzathine benzylpenicillin may also interact with some bacteriostatic drugs, such as chloramphenicol or tetracyclines.,
Ref :-   Book : Martindale    Page : 230   Edition : 38,


►  Contraindication : hypersensitive to penicillins, intrathecal route, Skin contact,
Ref :-   Book : Martindale    Page : 229,230   Edition : 38,
  ►  Mechanism of Action :   Benzylpenicillin inhibits the bacterial growth by interfearing with the transpeptidation reaction of bacterial cell wall synthesis. Benzylpenicillin is a structural analog of the natural D-Ala-D-Ala substrate, covalently bind to the active site of PBPs. This inhibits the transpeptidation reaction, halting peptidoglycan synthesis, and the cell dies. The exact mechanism of cell death is not completely understood, but autolysins and disruption of cell wall morphogenesis are involved.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 792   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Red algae with Another pathway,

  ►  Pathway with its reference as follows :-
  • Antibiotic effect --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal, Biliary, breast milk,
    Ref :-   Book : Martindale    Page : 230   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   30 min,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 230   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   15 min,    Max value :-   30 min,
    Ref :-   Book : Martindale    Page : 230   Edition : 38,