Betamethasone is a Medicine belongs to Corticosteroid group whose information about Brand can be referenced from   Book : Martindale    Page : 1624   Edition : 38   Martindale    Page : 1658   Edition : 37  

  ►   Brandname : Betnelan, Betnesol, Betacap, Beta-Val, Betnovate, Beisong, Bemon
  ►  Strength : Syrup with 0.6 mg/5mL.  Injection with 4 mg/ml.  Cream with .  Ointment with .  Lotion with .  drops with .  Tablet with .  Aerosol with

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 712   Edition : 12   Martindale    Page : 1624   Edition : 38  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Topical, IM, IV, intra-articular injection, intralesional injection, inhalation
Reference :-   Book : Martindale    Page : 1657   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Systemic therapy IM or IV 4 20 mg Injection Given as sodium phosphate ester in these equivalent doses of betamethasone. Doses may be repeated 3 or 4 times in 24 hours if necessary, depending on the condition being treated and the clinical response.
2 Local therapy Local 4 8 mg Injection given as sodium phosphate ester in these equivalent doses of betamethasone.
3 Allergic and inflammatory conditions of the eyes, ears, or nose Topical 0.1 % Given as Betamethasone sodium phosphate drops or ointment.
4 Various skin disorders Topical The dipropionate and valerate esters of betamethasone are extensively used in creams, ointments, lotions, and scalp applications. The usual concentrations available are the equivalent of 0.05% of betamethasone as the dipropionate, and 0.025 or 0.1% as the valerate.

Ref :-  Book : Martindale    Page : 1624   Edition : 38  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Systemic therapy up to 1 Year IV 1 mg Injection
2 Systemic therapy 1 Year 5 Year IV 2 mg Injection
3 6 Year 12 Year IV 4 mg Injection

Ref :- Book : Martindale    Page : 1624   Edition : 38  
Precaution :- If a Patient is using 'Betamethasone' drug in  PEPTIC ULCER DISEASE  disease, then Please do not use .

►  Side Effect : Menstrual irregularities, Amenorrhoea, Hyperhidrosis, Skin thinning, Ocular changes, Glaucoma, Cataract, Benign intracranial hypertension, Acute pancreatitis, Avascular necrosis of bone, Corneal ulcers, Raised intra-ocular pressure, Reduced visual function, Dryness, Irritation, Epistaxis, Neurological disturbances, Osteoporosis, Muscle wasting, Hyperglycemia, Insulin requirements of diabetic patients are increased, Increased susceptibility to all kinds of infection, Hypersenstivity, Adrenal atrophy
Ref :-   Book : Martindale    Page : 1629   Edition : 37.  

►  Drug Interaction : Drug interaction of Betamethasone is with Salicylates, Barbiturates , Oral Contraceptive, Potassium-depleting diuretics, Thiazide Diuretics , Xanthines, Beta 2 Agonist, NONSTEROIDAL ANTI-INFLAMMATORY DRUGS, Anticoagulant , Antidiabetic drugs, Antihypertensive Agents , anticholinesterases,  Carbamazapine , Phenytoin , Primidone , Rifampicin , Ritonavir, Mifepristone , Amphotericin B
Ref :-   Book : Martindale    Page : 1619   Edition : 38.  

  ►    Mechanism of Drug Drug Interaction :  Concurrent use of barbiturates, carbamazepine, phenytoin, primidone, or rifampicin may enhance the metabolism and reduce the effects of systemic corticosteroids. Conversely oral contraceptives or ritonavir may increase plasma concentrations of corticosteroids. Use of corticosteroids with potassium-depleting diuretics, such as thiazides or furosemide, may cause excessive potassium loss. There is also an increased risk of hypokalaemia with concurrent amphotericin B or bronchodilator therapy with xanthines or beta2 agonists. There may be an increased incidence of gastrointestinal bleeding and ulceration when corticosteroids are given with NSAIDs. Response to anticoagulants may be altered by corticosteroids and requirements of antidiabetic drugs and antihypertensives may be increased. Corticosteroids may decrease serum concentrations of salicylates and may decrease the effect of anticholinesterases in myasthenia gravis. The antiglucocorticoid effect of mifepristone will antagonise the effects of corticosteroids.
Ref :-   Book : Martindale    Page : 1619   Edition : 38.  

►  Contraindication : Active or doubtfully quiescent tuberculosis, Acute infections uncontrolled by appropriate antimicrobial therapy, Live vaccines not given to patients receiving high-dose systemic corticosteroid therapy nor for at least 3 months afterwards, Long-term topical use in children, Not applied with an occlusive dressing to large areas of the body, Not used for the treatment of rosacea, Not used for the treatment of ulcerative conditions, Not used indiscriminately for the treatment of pruritus, Rapid intravenous injection of massive doses of corticosteroids
Ref :-   Book : Martindale    Page : 1618   Edition : 38.  
  ►  Mechanism of Action :   Corticosteroids binds to specific receptor protiens in target tissues to regulate the expression of corticosteroid-responsive genes, thereby changing the levels and array of proteins synthesized by the various target tissues.
Ref :-   Book : Goodman    Page : 1216   Edition : 12.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Breast milk, Hepatic (Metabolism), Renal
Ref :-   Book : Martindale    Page : 1620   Edition : 38.  

►    Plasma Half-life :   Min value :-   36 hrs,    Max value :-   72 hrs.  
Ref :-   Book : Goodman    Page : 1216   Edition : 12.  

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA