Bevacizumab is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 750   Edition : 37,

  ►   Brandname : Avastin

  ►  Strength : Injection with 25  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 999   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Goodman    Page : 1739   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Colorectal cancer IV 5 10 mg/kg Injection given once every 2 weeks
2 Breast cancer IV 10 mg/kg Injection given once every 2 weeks.
3 Non-small cell lung cancer IV 7.5 15 mg/kg Injection given once every 3 weeks.
4 Renal cell carcinoma IV 10 mg/kg Injection given once every 2 weeks.
5 Glioblastoma IV 10 mg/kg Injection Given once every 2 weeks.

Ref :-  Book : Martindale    Page : 749   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : hypertensive crisis, impaired wound healing, gastrointestinal perforation, nephrotic syndrome, neuropathy, Dizziness, headache, gastrointestinal disturbance, Arterial thromboembolism,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 715   Edition : 3,

►  Drug Interaction : Drug interaction of Bevacizumab is with Sunitinib,
Ref :-   Book : Martindale    Page : 748.2   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  The US manufacturer of bevacizumab has recommended that it should not be used with sunitinib after several patients receiving the combination had developed microangiopathic haemolytic anaemia.,
Ref :-   Book : Martindale    Page : 749   Edition : 37,


►  Contraindication : Hypersensitivity,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 715   Edition : 3,
  ►  Mechanism of Action :   Bevacizumab is a recombinant humanised monoclonal antibody that binds to vascular endothelial growth factor (VEGF), thereby inhibiting the angiogenesis that occurs during tumour growth.,
Ref :-   Book : Martindale    Page : 749   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Vinca with Another pathway,

  ►  Pathway with its reference as follows :-
  • Vincristine and Vinblastine produces Anti Cancer effect --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   NA


    ►    Plasma Half-life :
      Min value :-   20 days,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 748   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA