Bezafibrate is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1325   Edition : 38  

  ►   Brandname : Beza, Bezalip, Bezagen, Bizalip, Abeita, Befibrat
  ►  Strength : Tablet with

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1325   Edition : 38  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 1357   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Hyperlipidaemias Oral 200 mg Tablet t.i.d. taken with or after food.

Ref :-  Book : Martindale    Page : 1357   Edition : 37  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Hyperlipidaemias 10 Year over 10 years Oral 200 mg o.d.

Ref :- Book : Martindale    Page : 1323   Edition : 38  
►  Side Effect : Anorexia, Nausea, Headache, Dizziness, Vertigo, Fatigue, Skin rashes, pruritus, Photosensitivity, Alopecia, impotence, Anaemia, leucopenia, Thrombocytopenia, Myopathy, Gastric discomfort, Raised serum-aminotransferase concentrations, Elevated creatine phosphokinase concentrations, Myositis
Ref :-   Book : Martindale    Page : 1356   Edition : 37.      Page :    Edition : .  

►  Drug Interaction : Drug interaction of Bezafibrate is with Oral anticoagulants, , Antidiabetic drugs, Statins, , ,  Tolbutamide , Phenytoin , Furosemide , Cyclosporine , Warfarin
Ref :-   Book : Martindale    Page : 1357   Edition : 37.  

  ►    Mechanism of Drug Drug Interaction :  Bezafibrate and other fibrates are highly protein-bound and may displace other drugs from protein binding sites. Interactions may also occur through changes in the activity of cytochrome P450 isoenzymes, particularly CYP3A4. Fibrates may enhance the effects of oral anticoagulants; the dose of anticoagulant should be reduced when treatment with a fibrate is started, and then adjusted gradually if necessary. The mechanism of the interaction is unclear; fibrates have been reported to displace warfarin from protein binding sites but other mechanisms are probably also involved. Other drugs that may be displaced from plasma proteins by fibrates include tolbutamide and other sulfonylurea antidiabetics, phenytoin, and, in patients with hypoalbuminaemia, furosemide. The interaction with antidiabetics is complex since fibrates may alter glucose tolerance in diabetic patients. There is an increased risk of myopathy if fibrates are used with statins. Fibrates may interact with ciclosporin, although reports have been conflicting nephrotoxicity associated with increased ciclosporin concentrations has been reported with bezafibrate and renal function should be monitored. Cholestasis has been reported in a patient given fenofibrate with raloxifene.
Ref :-   Book : Martindale    Page : 1325   Edition : 38.  

►  Contraindication : Gallstones or gallbladder disorders, Hypoalbuminaemic states such as nephrotic syndrome, If creatinine clearance is below 15 mL/minute, Not given with statins in patients with risk factors for myopathy, Severe hepatic impairment
Ref :-   Book : Martindale    Page : 1324   Edition : 38.  
  ►  Mechanism of Action :   Benzfibrate, a fibric acid derivative, is a lipid regulating drug. Fibrates reduce triglycerides by reducing the concentration of very-low-density lipoprotein (VLDL). They reduce low-density lipoprotein (LDL)-cholesterol to a lesser extent, although the effect is variable, and may also increase high-density lipoprotein (HDL)- cholesterol. Although evidence that this leads to a reduction in cardiovascular events is less good than for statins, some fibrates may have a role in cardiovascular risk reduction.
Ref :-   Book : Martindale    Page : 1357   Edition : 37.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal, Fecal
Ref :-   Book : Martindale    Page : 1357   Edition : 37.  

►    Plasma Half-life :   Min value :-   1 hours,    Max value :-   2 hours.  
Ref :-   Book : Martindale    Page : 1357   Edition : 37.  

►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
Ref :-   Book :    Page :    Edition : .