Bisoprolol fumarate is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1326   Edition : 38   Martindale    Page : 1326   Edition : 38  

  ►   Brandname : Concor, Bebedol, Cardicor, Zebeta, Bicard, An Shi, Bisobeta
  ►  Strength : Tablet with 5 Mg.  Tablet with 10 Mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 189   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 1358   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 hypertension Oral 5 10 mg Tablet o.d.
2 Angina pectoris Oral 5 10 mg Tablet o.d.
3 Heart failure Oral 1.25 mg Tablet o.d.

Ref :-  Book : Martindale    Page : 1325   Edition : 38  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 hypertension 0.04 mg/kg/day

Ref :- Book : Nelson's textbook of Pediatrics    Page : 1645   Edition : 19  
►  Side Effect : Bradycardia, Hypotension, Fatigue, Paraesthesia, Arthralgia, Muscle cramps, Coldness of the extremities, Nausea, Vomiting, Diarrhea, Constipation, Abdominal cramping, Hypoglycemia, Hyperglycaemia, Skin rashes, pruritus, Exacerbation of psoriasis, Excess sweating, Reversible alopecia, Nonthrombocytopenic purpura, Thrombocytopenia, Transient eosinophilia, Headache, Depression, Dizziness, Hallucinations, Confusion, Sleep disturbances, heart block, Heart failure, , Abrupt withdrawal of beta blockers may exacerbate angina and may lead to sudden death, Bronchospasm
Ref :-   Book : Martindale    Page : 1349   Edition : 37.  

►  Drug Interaction : Drug interaction of Bisoprolol fumarate is with Angiotensin converting enzyme inhibitor, Calcium Channel Blockers , General anaesthetics , NONSTEROIDAL ANTI-INFLAMMATORY DRUGS, Antiarrhythmics, Oral Hypoglycemic Drugs, , , Barbiturates ,  Rifampicin , Cimetidine , Erythromycin , Fluvoxamine, Hydralazine , Clonidine , Aldesleukin , Verapamil , Digoxin , Insulin
Ref :-   Book : Martindale    Page : 1352   Edition : 37.  

  ►    Mechanism of Drug Drug Interaction :  Drugs that enhance the antihypertensive effects of beta blockers, such as ACE inhibitors, calcium-channel blockers, and clonidine may be useful in controlling hypertension. Drugs that cause hypotension such as aldesleukin and general anaesthetics also enhance the antihypertensive effects of beta blockers while other drugs, for example NSAIDs, antagonise the antihypertensive effects. Use of beta blockers with other cardiac depressants such as antiarrhythmics and rate-limiting calcium channel blockers can precipitate bradycardia and heart block; the combination of intravenous verapamil and beta blockers should especially be avoided. Beta blockers may potentiate bradycardia due to digoxin. In diabetic patients beta blockers can reduce the response to insulin and oral hypoglycaemics through their effects on pancreatic beta receptors. Drugs that reduce absorption include aluminium salts and bile-acid binding resins such as colestyramine. Metabolism of some beta blockers can be increased by drugs such as barbiturates and rifampicin and decreased with drugs such as cimetidine, erythromycin, fluvoxamine, and hydralazine. Drugs that alter hepatic blood flow also affect metabolism of some beta blockers. For example, cimetidine and hydralazine decrease hepatic blood flow and this contributes to the decreased hepatic clearance seen with these drugs.
Ref :-   Book : Martindale    Page : 1321   Edition : 38.  

►  Contraindication : Asthma, Bronchospasm, Cardiogenic shock, Hypotension, Metabolic acidosis, Second -or- third degree AV block, Severe peripheral arterial disease, Sinus bradycardia, Uncontrolled heart failure, History of obstructive airways disease, Patients with phaeochromocytoma should not be given beta blockers without alpha-adrenoceptor blocking therapy
Ref :-   Book : Martindale    Page : 1320   Edition : 38.  
  ►  Mechanism of Action :   Antagonize sympathetic stimulation of β1 adrenergic receptors in SA and AV nodal cells, thereby decreasing slope of phase 4 depolarization (important at SA node) and prolonging repolarization (important at AV node).
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 419   Edition : 3.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal, Hepatic (Metabolism)
Ref :-   Book : Martindale    Page : 1358   Edition : 37.  

►    Plasma Half-life :   Min value :-   10 hours,    Max value :-   12 hours.  
Ref :-   Book : Martindale    Page : 1358   Edition : 37.  

►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   4 hours.  
Ref :-   Book : Martindale    Page : 1358   Edition : 37.