Bleomycin is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 752   Edition : 38,

  ►   Brandname : Bledmax,Bleo,bleochem,Blenamax,Bleo-cell

  ►  Strength : Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 752   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, IM, SC, intraarterial, Intrapleural, Intraperitoneal,
Reference :-   Book : Martindale    Page : 753   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Testicular cancer 30 mg Injection Given by the intravenous, intramuscular, or subcutaneous route; It is standard total dose which is given weekly for 3 consecutive weeks
2 Malignant pleural effusions Local 5 60 mg The dose to be used depends on the technique; and it is Instilled into the pleural cavity.

Ref :-  Book : Goodman    Page : 1717   Edition : 12,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Rashes, erythema, pruritus, vesiculation, hyperkeratosis, nail changes, alopecia, hyperpigmentation, striae, stomatitis, fever, acute anaphylactoid reactions, hyperpyrexia, cardiorespiratory collapse reported in 1% of patients with lymphoma, little depression of the bone marrow, Local reactions, thrombophlebitis, pulmonary toxicity, interstitial pneumonitis, fibrosis and death in 1% of patients,
Ref :-   Book : Martindale    Page : 751   Edition : 37, Martindale    Page : 751   Edition : 38,

►  Drug Interaction : Drug interaction of Bleomycin is with NA

  ►    Mechanism of Drug Drug Interaction :  There may be an increased risk of pulmonary toxicity in patients given bleomycin who receive oxygen, for example as part of a general anaesthetic procedure; a reduction in inspired oxygen concentration has been recommended.,
Ref :-   Book : Martindale    Page : 751   Edition : 38,


►  Contraindication : Hypersensitivity,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 696   Edition : 3,
  ►  Mechanism of Action :   Bleomycin's cytotoxicity results from its ability to cause oxidative damage to the deoxyribose thymidylate and other nucleotides leading to single and double stranded breaks DNA. Bleomycin cleaves DNA by generating free radical in the presence of oxygen and reducing agent, such as dithiothreitol, the metal drug complex become activated and function as a ferrous oxidase transferring electron fe++ to molecular oxygen to produce oxygen radicals.,
Ref :-   Book : Goodman    Page : 1716   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Turmeric with Another pathway,

  ►  Pathway with its reference as follows :-
  • Curcumin block the transformation, proliferation and invasion of tumor cells, curcumin suppresses the growth of several tumor cell lines, including drug resistant lines. --- (18. PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Goodman    Page : 1717   Edition : 12,


    ►    Plasma Half-life :
      Min value :-   3 hours,    Max value :-   NA
    Ref :-   Book : Goodman    Page : 1717   Edition : 12,

    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,