Bortezomib is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 753   Edition : 38,

  ►   Brandname : Bortenat,Mibor,Velcade

  ►  Strength : Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 752   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Martindale    Page : 753   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Previously untreated multiple myeloma IV 1.3 mg/m2 Injection Given on days 1, 4, 8, 11, 22, 25, 29, and 32 of a 42-day cycle for 4 cycles. Melphalan (9 mg/m2) and prednisone (60 mg/m2) are given orally on days 1 to 4 of each cycle.
2 Relapsed/refractory multiple myeloma and mantle cell lymphoma IV bolus 1.3 mg/m2 Injection Given on days 1, 4, 8, and 11 of a 21-day cycle. At least 72 hours should elapse between consecutive doses of bortezomib.

Ref :-  Book : Martindale    Page : 752   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Transient thrombocytopenia, fatigue, peripheral neuropathy, transient neutropenia, and anaemia, Gastrointestinal disturbances, decreased appetite, nausea, dyspnoea, Rashes, hyperglycemia, hypokalaemia, insomnia, anxiety, Confusion, Depression, dry mouth, eye pain, vertigo, Dysgeusia, epistaxis, Cough, rhinorrhoea, pruritus, eye pain, tremor, Orthostatic hypotension, hypertension, bone pain, arthralgia, tachycardia, angina pectoris, atrial fibrillation, myocardial infarction, Acute renal failure, dysuria, urinary frequency or incontinence, urinary retention, haematuria, proteinuria, haemorrhagic cystitis have been reported, reversible hepatotoxicity, Increase in liver enzyme values, acute liver failure, tumour lysis syndrome, isolated cases of QT-interval prolongation, ,
Ref :-   Book : Martindale    Page : 752,753   Edition : 38,

►  Drug Interaction : Drug interaction of Bortezomib is with , ,  Ketoconazole ,
Ref :-   Book : Martindale    Page : 753   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Bortezomib is metabolised in the liver via the cytochrome P450 isoenzymes CYP3A4, CYP2C19, and CYP1A2. Bortezomib is a weak inhibitor of CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4. Ketoconazole (potent CYP3A4 inhibitor) increased exposure to bortezomib. Patients should be monitored closely when bortezomib is used with other drugs that induce or inhibit CYP3A4. Hypoglycaemia and hyperglycaemia have occurred in diabetic patients receiving oral antidiabetics who were given bortezomib. ,
Ref :-   Book : Martindale    Page : 753   Edition : 38,


►  Contraindication : Hypersensitivity to bortezomib, boron, or mannitol,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 714   Edition : 3,
  ►  Mechanism of Action :   Bortezomib is an inhibitor of the 26S proteasome, a large protein complex in cells that is responsible for breaking down regulatory proteins of the cell cycle. Such inhibition disrupts tumour cell turnover and induces apoptosis.,
Ref :-   Book : Martindale    Page : 753   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Vinca with Another pathway,

  ►  Pathway with its reference as follows :-
  • Anticancer . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Hepatic (Metabolism),
    Ref :-   Book : Martindale    Page : 753   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   24 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 753   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   about 1hr,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 753   Edition : 38,