Brimonidine is a Medicine belongs to antiglaucoma drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 2005   Edition : 38,

  ►   Brandname : Brimodin,Lobrim,Alphagan,Mirvaso,Enidin,Brimo Ophtal,Brimocon

  ►  Strength : Ophthalmic Solution with 0.15  %, Ophthalmic Solution with 0.2  %,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 148   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Topical,
Reference :-   Book : Basic & Clinical pharmacology    Page : 148   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Glaucoma Topical 0.1 % Eye Drop b.d/t.i.d Given as brimonidine tartrate; also 0.15, or 0.2% conc. may be instilled two or three times daily.
2 Ocular hypertension Topical 0.1 % Eye Drop b.d/t.i.d Given as brimonidine tartrate; also 0.15, or 0.2% conc. may be instilled two or three times daily.

Ref :-  Book : Martindale    Page : 2004   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : hypotension, Sedation,
Ref :-   Book : Goodman    Page : 297   Edition : 12,

►  Drug Interaction : Drug interaction of Brimonidine is with , Tricyclic antidepressants, Monoamine Oxidase Inhibitor, ,  Clonidine ,
Ref :-   Book : Martindale    Page : 2004   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Systemic absorption may occur after topical application of brimonidine to the eye and there is a theoretical possibility of interactions similar to those reported with clonidine. MAOIs should not be given with Brimonidine; tricyclic and related antidepressants and systemic sympathomimetics should also be avoided or used with caution.,
Ref :-   Book : Martindale    Page : 2004   Edition : 38,


►  Contraindication : NA
  ►  Mechanism of Action :   Brimonidine; topical alpha2-adrenoceptor agonist, lower intra-ocular pressure by reducing production of aqueous humour.,
Ref :-   Book : Martindale    Page : 1999   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Makandi with Another pathway, Leaf of Pilocarpus with Another pathway,

  ►  Pathway with its reference as follows :-
  • decrease intraoccular pressure --- (c, K. (2010). Coleus forskohlii: A comprehensive review on morphology, phytochemistry and pharmacological aspects C.Kavitha 1* , K. Rajamani 2 and E. Vadivel 3. Journal of Medicinal Plants Research, Vol. 4(4) pp. 278-285, 18 February, 2010, 4(4). )
  • Pilocarpine, Pilosine --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://www.academicjournals.org/article/article1380523712_Kavitha%20et%20al.pdf, http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy, +C.+K.+Kokate, +A.P.+Purohit, +S.B.+Gokhale,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- YOHIMBE with The active ingredients in yohimbe can block the actions of brimonidine in certain human tissues , thus reducing the drugs beneficial effects .,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,

    ►   Route of Elimination :   NA


    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA