Brinzolamide is a Medicine belongs to Diuretic Agents group whose information about Brand can be referenced from   Book : Martindale    Page : 2005   Edition : 38  

  ►   Brandname : Azopt
  ►  Strength : ophthalmic suspension with 1 %. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 269   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Topical
Reference :-   Book : Martindale    Page : 2005   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Open-angle glaucoma Topical 1 % ophthalmic suspension b.d/t.i.d Given also for ocular hypertension.

Ref :-  Book : Martindale    Page : 2005   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Conjunctivitis, Keratitis, Burning , Stinging, Eyelid inflammation or irritation, Corneal oedema and irreversible corneal decompensation have been reported in patients with pre-existing chronic corneal defects and/or a history of intra-ocular surgery
Ref :-   Book : Martindale    Page : 2005, 2007   Edition : 38.  

►  Drug Interaction : Drug interaction of Brinzolamide is with NA

  ►    Mechanism of Drug Drug Interaction : 
Ref :-   Book :    Page :    Edition : .  


►  Contraindication : NA
  ►  Mechanism of Action :   Inhibition of the carbonic anhydrase enzyme prevents dehydration of H2CO3 and hydration of CO2 in the proximal convoluted tubule. Reduces reabsorption of HCO3 −, causing self-limited diuresis and hyperchloremic metabolic acidosis reduces body pH, and reduces intraocular pressure.
Ref :-   Book : Basic & Clinical pharmacology    Page : 268   Edition : 12.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Resveratrol with same pathway.   Catechin with same pathway.   Silymerin with same pathway.   Curcumin with same pathway.   Leaf of Pilocarpus with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Carbonic anhydrase inhibitor --- ( M, S. and I, c. (2011). In Vitro inhibition of human carbonic anhydrase I and II isozymes with natural phenolic compounds. pmid, 77(6). )
  • Carbonic anhydrase inhibitor --- ( M, s. and I, g. (2011). In Vitro inhibition of human carbonic anhydrase I and II isozymes with natural phenolic compounds. pubmed, 77(6). )
  • Carbonic anhydrase inhibitor --- (: M, S. and I, c. (2011). In Vitro inhibition of human carbonic anhydrase I and II isozymes with natural phenolic compounds. pmid, 77(6). )
  • Pilocarpine Pilosine produces contraction of the iris sphincter muscle, resulting in pupillary constriction (miosis). --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • Carbonic anhydrase inhibitor --- (M, S. and I, c. (2011). In Vitro inhibition of human carbonic anhydrase I and II isozymes with natural phenolic compounds. pmid, 77(6). )

  •   ►  URL --
  • http://www.ncbi.nlm.nih.gov/pubmed/21332948 .
  • http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   NA

    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA