Bromocriptine is a Medicine belongs to Antiparkinsonian Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 899   Edition : 38, Martindale    Page : 885   Edition : 37,

  ►   Brandname : Briptin,Parlodel,Brom,Cycloset,Kripton,Kirim

  ►  Strength : Tablet with 2.5  Mg, Capsule with 5  Mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 678   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM,
Reference :-   Book : Martindale    Page : 885   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Prevention of puerperal lactation Oral 2.5 mg Tablet This dose is given on the day of delivery followed by 2.5 mg twice daily for 14 days. The risk of hypotension and, more rarely, hypertension must be borne in mind and it has been recommended that bromocriptine should not be given until at least 4 hours after delivery.
2 Suppression of established lactation Oral 2.5 mg Tablet given daily for 2 to 3 days and subsequently increased to 2.5 mg twice daily for 14 days.
3 Treatment of hypogonadism and galactorrhoea syndromes and infertility Oral 1.25 2.5 mg Tablet it is a usual starting dose given daily increased by 2.5 mg every 2 to 7 days.
4 Used as an adjunct to surgery and radiotherapy to reduce plasma-growth hormone concentrations in acromegalic patients oral / i.m 1.25 2.5 mg Given daily and increased by 2.5 mg every 2 to 7 days and may then be increased further by 2.5 mg every 2 to 3 days if necessary up to 5 mg every 6 hours, according to response.
5 Type 2 diabetes mellitus Oral 800 micrograms Used as an adjunct. Given daily and increased in weekly steps of 800 micrograms according to mtolerance.
6 Parkinson’s disease Oral 1.25 100 mg Tablet b.d. In Parkinson’s disease bromocriptine has been used alone, although it is usually given as an adjunct to levodopa treatment. Usual starting dose is 1.25 to 2.5 mg twice daily increased by 2.5 mg every 14 to 28 days to a maximum dose of 100 mg daily if necessary.

Ref :-  Book : Martindale    Page : 884,885.   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : nausea, vomiting, Orthostatic hypotension, syncope, Raynaud’s syndrome, erythromelalgia, prolonged severe hypotension, Arrhythmias, retroperitoneal fibrosis, pleural thickening and effusions, altered liver function tests, dyskinesia, gastrointestinal bleeding, Dizziness, psychomotor excitation, digital vasospasm, leg cramps, pericarditis, pericardial effusion, , constipation, diarrhoea, Psychosis, hallucinations,
Ref :-   Book : Martindale    Page : 882   Edition : 37, Martindale    Page : 882   Edition : 37,    Page :    Edition : ,

►  Drug Interaction : Drug interaction of Bromocriptine is with Phenothiazine, Butyrophenone, Thioxanthenes , Metoclopramide , Memantine hydrochloride , Octreotide ,
Ref :-   Book : Martindale    Page : 884   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Dopamine antagonists such as the phenothiazines, butyrophenones, thioxanthenes, and metoclopramide might be expected to reduce the prolactin- lowering and the antiparkinsonian effects of bromocriptine and domperidone might reduce its prolactin- lowering effect. Memantine may enhance the effects of bromocriptine. Stimulants of gastrointestinal motility such as macrolide antibacterials or octreotide can increase the bioavailability of bromocriptine,
Ref :-   Book : Martindale    Page : 884   Edition : 37,


►  Contraindication : Hypersensitivity to ergot derivatives, toxemia of pregnancy, Uncontrolled hypertension,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 478   Edition : 3,
  ►  Mechanism of Action :   Bromocriptine act by direct stimulation of remaining postsynaptic dopamine D2-agonist receptors. By doing so it inhibits the secretion of prolactin from the anterior pituitary and is used in the treatment of prolactinoma and endocrinological disorders associated with hyperprolactinaemia.,
Ref :-   Book : Martindale    Page : 889,895    Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Ergot with Another pathway, Fava beans i.e. bakla with same compound,

  ►  Pathway with its reference as follows :-
  • Ergot alkaloid --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • Fava beans rich in levo-dihydroxyphenylalanine(L-Dopa) the precursor of dopamine. --- (Mehran S.M., Mohseni. "Simultaneous Determination Of Levodopa And Carbidopa From Fava Bean, Green Peas And Green Beans By High Performance Liquid Gas Chromatography". JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH (2013): n. pag. Web. 10 Nov. 2016. )

  •   ►  URL -- http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy, +C.+K.+Kokate, +A.P.+Purohit, +S.B.+Gokhale, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708185/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- AGNUS CASTUS I.E. NIRGANDHI with Nirgandhi interact with dopamine agonist drug , ALPHA-LIPOIC ACID with long term supplementation require some change in dosage of diabes medicine .,

      ►  Reference :-
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf, https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,

    ►   Route of Elimination :   Fecal, Hepatic (Metabolism), Renal, Biliary,
    Ref :-   Book : Martindale    Page : 884   Edition : 37, Martindale    Page : 884   Edition : 38,


    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   3 hours,
    Ref :-   Book : Martindale    Page : 884   Edition : 37,