Buclizine is a Medicine belongs to antihistamines group whose information about Brand can be referenced from   Book : Martindale    Page : 619   Edition : 38  

  ►   Brandname : Longifene
  ►  Strength : Tablet with 50 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 292   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 619   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 For most indications including the prevention of motion sickness Oral 25 50 mg Tablet Given daily. And in severe cases up to 100 mg daily has been given.
2 Migraine Given in usual doses of 12.5 mg at the start of an attack or when one is known to be imminent.

Ref :-  Book : Martindale    Page : 619   Edition : 38  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Management of allergic conditions and as an antiemetic 5 Year 10 Year Oral 12.5 30 mg
2 Migraine 10 Year 14 Year

Ref :- Book : Martindale    Page : 619   Edition : 38  
►  Side Effect : Most common adverse effects are, CNS depression, Lassitude, Dizziness, Incoordination, Other common adverse effects include, Headache, Psychomotor impairment, Dry mouth, Thickened respiratory-tract secretions, Blurred Vision, Urinary difficulty or retention, Constipation, Gastric reflux, Other occasional adverse effects include, Nausea, Vomiting, Diarrhea, Epigastric pain, Arrhythmias, palpitations, Sometimes cause rashes and hypersensitivity reactions, Bronchospasm, Anaphylaxis
Ref :-   Book : Martindale    Page : 613,619   Edition : 38.  

►  Drug Interaction : Drug interaction of Buclizine is with Alcohol, Barbiturates , Hypnotics, opioid analgesics, Anxiolytic sedatives, Antipsychotics, , Aminoglycoside antibiotic ,  Atropine
Ref :-   Book : Martindale    Page : 614,619   Edition : 38.  

  ►    Mechanism of Drug Drug Interaction :  Sedating antihistamines may enhance the sedative effects of CNS depressants including alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives, and antipsychotics. Sedating antihistamines have an additive antimuscarinic action with other antimuscarinic drugs, such as atropine and some antidepressants (both tricyclics and MAOIs). It has been suggested that some sedating antihistamines could mask the warning signs of damage caused by ototoxic drugs such as aminoglycoside antibiotics. Antihistamines may suppress the cutaneous histamine response to allergen extracts and should be stopped several days before skin testing.
Ref :-   Book : Martindale    Page : 614,619   Edition : 38.  

►  Contraindication : Alcohol, Those affected should not drive or operate machinery, Neonates
Ref :-   Book : Martindale    Page : 613,619   Edition : 38.  
  ►  Mechanism of Action :   Buclizine hydrochloride, a piperazine derivative, is a sedating antihistamine with antimuscarinic and moderate sedative actions.
Ref :-   Book : Martindale    Page : 619   Edition : 38.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   NA

►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA