Bumetanide is a Medicine belongs to Diuretic Agents group whose information about Brand can be referenced from   Book : Martindale    Page : 1329   Edition : 38  

  ►   Brandname : Bai Chang, Burinex

  ►  Strength : Tablet with 0.5 Mg.  Tablet with 1 Mg.  Tablet with 2 Mg.  Injection with 0.5 mg/2 ml. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 269   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV, IM
Reference :-   Book : Martindale    Page : 1362   Edition : 37  


Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Oedema Oral 1 mg given in the morning or early evening
2 Pulmonary oedema IV 1 2 mg Injection repeated 20 minutes later if necessary.
3 hypertension Oral 0.5 1 mg o.d.
4 Oedema Oral 1 mg given in the morning or early evening.
5 Refractory oedema Oral 5 mg o.d.
6 Pulmonary oedema IV 1 2 mg Injection
7 hypertension Oral 0.5 1 mg o.d.

Ref :-  Book : Martindale    Page : 1362   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Oedema >=1 Month Oral 15 50 micrograms/kg
2 Oedema >=1 Month IV 15 50 micrograms/kg infusion

Ref :- Book : Martindale    Page : 1362   Edition : 37  
►  Side Effect : Volume contraction alkalosis, Ototoxicity, Hypokalaemia, Hyperuricaemia, Hypomagnesemia, Muscle cramps, Hyperglycaemia, Blurred Vision, Agranulocytosis, Thrombocytopenia, leucopenia, Glycosuria, Dyspepsia, Hypotension, Erythema multiforme, Stevens-Johnson syndrome, Pancreatitis, Aplastic anaemia, Or hemolytic anemia
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 351   Edition : 3.      Page :    Edition : .  

►  Drug Interaction : Drug interaction of Bumetanide is with Cephalosporin , Aminoglycoside antibiotic , ,  NA


  ►    Mechanism of Drug Drug Interaction :  The interactions of bumetanide that are due to its effects on fluid, electrolyte and carbohydrate balance. Bumetanide may enhance the nephrotoxicity of cephalosporin antibacterials such as cefalotin and can enhance the ototoxicity of aminoglycoside antibacterials and other ototoxic drugs.
Ref :-   Book : Martindale    Page : 1329, 1389   Edition : 38.  


►  Contraindication : Anuria, Hypersensitive to sulfonamides, Co-administration with aminoglycosides
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 351   Edition : 3.  
  ►  Mechanism of Action :   Bumetanide inhibits the reabsorption of electrolytes primarily in the thick ascending limb of the loop of Henle and also in the distal renal tubules. It may also have a direct effect in the proximal tubules. Excretion of sodium, potassium, calcium, and chloride ions is increased and water excretion enhanced. It has no clinically significant effect on carbonic anhydrase.
Ref :-   Book : Martindale    Page : 1329,1387   Edition : 38.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- Tea with Another pathway.  

  ►  Pathway with its reference as follows :-
  • diuretics effect . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

    •   ►  URL --
  • http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html .
    •


    DIETARY Substance Interactions

    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance

    ​   ► This Medicine contraindicate with :- ALOE VERA with Cause hypokalemia with potassium depleting diuretic ..  

      ►  Reference :-
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.

    •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf

    ►   Route of Elimination :   Renal, Faecal
    Ref :-   Book : Martindale    Page : 1329   Edition : 38.  

    ►    Plasma Half-life :   Min value :-   1 hours,    Max value :-   2 hours.  
    Ref :-   Book : Martindale    Page : 1329   Edition : 38.  

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA