Bupropion is a Medicine belongs to antidepressants group whose information about Brand can be referenced from   Book : Martindale    Page : 410   Edition : 38  

  ►   Brandname : Bupep, Bupron, Zyban, Aplenzin, Prexaton, Elontril, Le Fu Ting
  ►  Strength : Tablet with 25 mg.  Tablet with 50 mg.  Tablet with 75 mg.  Tablet with 100 mg.  sustained realease tablet with 100 mg.  sustained realease tablet with 150 mg.  sustained realease tablet with 200 mg.  sustained realease tablet with 300 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 539   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 415   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Depression Oral 100 150 mg Tablet b.d. Dose can be increased if necessary, after at least 3 days to 100 mg three times daily. In severe cases, if no improvement has been observed after several weeks of therapy, the dose may be increased further to a max. of 150 mg TDS.
2 Depression in patients with seasonal affective disorder Oral 300 mg sustained realease tablet o.d.
3 As an aid to smoking cessation Oral 150 mg sustained realease tablet o.d. Given for 6 days, increasing to 150 mg twice daily on day 7.

Ref :-  Book : Martindale    Page : 408   Edition : 38  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Depression Oral 75 450 mg
2 Attention deficit hyperactivity disorder Oral 75 450 mg

Ref :- Book : Nelson's textbook of Pediatrics    Page : 63, 111   Edition : 19  
Precaution :- If a Patient is using 'Bupropion' drug in  Generalized, Tonic-Clonic Seizures  disease, then Please Not to be given .

►  Side Effect : Agitation, Dizziness, Constipation, Tremor, Sweating, Skin rashes, Dyspepsia, pruritus, Blurred Vision, Seizure, Tachyarrhythmia, hypertension especially when combined with nicotine patch, May exacerbate mania in susceptible patients (effect less than other antidepressants)
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 222,223   Edition : 3.  

►  Drug Interaction : Drug interaction of Bupropion is with , , Quinolones, , Sedative antihistamines, Antipsychotics, Antimalarials, Alcohol,  Tramadol , Theophylline , Amantadine , Levodopa
Ref :-   Book : Martindale    Page : 414   Edition : 37.  

  ►    Mechanism of Drug Drug Interaction :  Bupropion should not be given with or within 14 days of stopping an MAOI; however, no treatment-free period is necessary after stopping a reversible inhibitor of monoamine oxidase type A (RIMA) and starting bupropion. The use of alcohol with bupropion should be minimised or avoided completely because it may alter the seizure threshold. Similarly, extreme caution is needed if other drugs that lower the seizure threshold, such as other antidepressants, antimalarials, antipsychotics, sedating antihistamines, quinolones, tramadol, theophylline, or systemic corticosteroids are used with bupropion. Use of nicotine transdermal patches with bupropion has been associated with hypertension, and patients using both should therefore have their blood pressure monitored. Caution has been advised in patients receiving either amantadine or levodopa with bupropion because of reports of a higher incidence of adverse effects in patients receiving these combinations.
Ref :-   Book : Martindale    Page : 410   Edition : 38.  

►  Contraindication : Concomitant use of MAO inhibitor, Seizure, Bulimia or anorexia, Concomitant use of other bupropion products, Electrolyte abnormalities, Patients undergoing abrupt discontinuation of alcohol or sedatives (including benzodiazepines)
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 222,223   Edition : 3.  
  ►  Mechanism of Action :   It is an aminoketone antidepressant that weakly inhibits neuronal uptake of 5-HT, dopamine and norepinephrine.
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 777   Edition : 3.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- YOHIMBE with The active ingredients in yohimbe can block the actions of brimonidine in certain human tissues , thus reducing the drugs beneficial effects ..  

  ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf

    ►   Route of Elimination :   Hepatic (Metabolism), Renal
    Ref :-   Book : Martindale    Page : 415   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   14 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 415   Edition : 37.  

    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : .