Buspirone is a Medicine belongs to Anxiolytics group whose information about Brand can be referenced from   Book : Martindale    Page : 1043   Edition : 38,

  ►   Brandname : Buscalm,Buson,Anxut,Buspar,Qibite

  ►  Strength : Tablet with 5  mg, Tablet with 7.5  mg, Tablet with 10  mg, Tablet with 15  mg, Tablet with 30  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 387   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1069   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Anxiety disorders Oral 5 60 mg Tablet b.d/t.i.d Used in the short-term management of anxiety disorders. The dose may be increased in increments of 5 mg at 2- to 3-day intervals, if required, to a usual range of 15 - 30 mg daily given in divided doses.

Ref :-  Book : Martindale    Page : 1042   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Anxiety 5 30 mg

Ref :- Book : Nelson's textbook of Pediatrics    Page : 63   Edition : 19,
►  Side Effect : Dizziness, nausea, headache, Nervousness, lightheadedness, excitement, paraesthesia, Sleep disturbances, chest pain, tinnitus, sore throat, nasal congestion, tachycardia, palpitations, drowsiness, Confusion, seizure, dry mouth, fatigue, sweating, less sedation, syndrome of restlessness appearing shortly after the start of treatment,
Ref :-   Book : Martindale    Page : 1068   Edition : 37,

►  Drug Interaction : Drug interaction of Buspirone is with , , Monoamine Oxidase Inhibitor, , Alcohol,  Ritonavir, Erythromycin , Rifampicin , Itraconazole , Nefazodone, Diltiazem , Verapamil ,
Ref :-   Book : Martindale    Page : 1043   Edition : 38, Martindale    Page : 1043   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  The sedative effects of buspirone may be enhanced if taken with alcohol or other CNS depressants. Because of reports of increased blood pressure in patients receiving buspirone hydrochloride with an MAOI, licensed product information for buspirone recommends that it should not be given with an MAOI. The metabolism of buspirone is mediated by the cytochrome P450 isoenzyme CYP3A4 and therefore there is the potential for interactions between buspirone and other drugs that inhibit, induce or act as a substrate for this isoenzyme. The dose of buspirone may need to be reduced if given at the same time as potent inhibitors of CYP3A4 such as diltiazem, erythromycin, itraconazole, nefazodone, ritonavir, and verapamil. Plasma concentrations of buspirone may be reduced by enzyme-inducing drugs such as rifampicin and the dosage of buspirone may need adjusting with such use. Grapefruit juice may also increase plasma conc. of buspirone and should be avoided.,
Ref :-   Book : Martindale    Page : 1043   Edition : 38,


►  Contraindication : Severe hepatic and renal impairment, epilepsy or a history of such disorders,
Ref :-   Book : Martindale    Page : 1043   Edition : 38,
  ►  Mechanism of Action :   Mechanism uncertain: Partial agonist at 5-HT receptors but also affinity for D2 receptors.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 386   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Ashwagandha with Another pathway,

  ►  Pathway with its reference as follows :-
  • Anti-anxity . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- 5 HTP(5-HYDROXYTRYPTOPHAN) with Cause anxiety, confusion and other side effect, KAVA with cause excessive drawsiness, CINNAMON with Increased risk of hypoglycaemia, bleeding ,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Posadzki, P., Watson, L., & Ernst, E. (2012). Herb-drug interactions: an overview of systematic reviews. British Journal Of Clinical Pharmacology, no-no. http://dx.doi.org/10.1111/j.1365-2125.2012.04350.x

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20, http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2012.04350.x/full,

    ►   Route of Elimination :   Fecal, Renal, Hepatic (Metabolism),
    Ref :-   Book : Martindale    Page : 1069   Edition : 37,


    ►    Plasma Half-life :   Min value :-   2 hours,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 1043   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   40 min,    Max value :-   90 min,
    Ref :-   Book : Martindale    Page : 1043   Edition : 38,