Calcium Disodium Edetate is a Medicine belongs to Chelators group whose information about Brand can be referenced from   Book : Martindale    Page : 1574   Edition : 38  

  ►   Brandname : Ledclair, Ledcure
  ►  Strength : Injection with

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1573   Edition : 38  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, IM
Reference :-   Book : Martindale    Page : 1573   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Severe toxicity IV infusion 80 mg/kg Injection daily in 2 divided doses, or 75 mg/kg once daily by i.v infusion over at least 1 hour.
2 Encephalopathy IV infusion 80 mg/kg Injection daily in 2 divided doses or 75 mg/kg once daily by i.v infusion over at least 1 hour.

Ref :-  Book : Martindale    Page : 1573   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Severe toxicity IV infusion 80 mg/kg Injection
2 Encephalopathy IV infusion 80 mg/kg Injection

Ref :- Book : Martindale    Page : 1574,1573   Edition : 38  
►  Side Effect : Glycosuria, Proteinuria, Renal proximal tubular necrosis, Microscopic Haematuria , Nephrotoxicity, , Thrombophlebitis, Gastrointestinal disturbance, Nausea, Diarrhoea, Abdominal pain, Chill, Fever, Malaise, Headache, Myalgia, Arthralgia, Histamine-like responses, Sneezing, Nasal congestion, Lachrymation, Transient hypotension, Cardiac rhythm irregularities, Increase in liver enzymes, Tremor, Numbness, Tingling, Cheilosis, Rashes, Transient bone marrow depression, Anaemia, Excessive thrist, Hypercalcaemia
Ref :-   Book : Martindale    Page : 1574   Edition : 38.  

►  Drug Interaction : Drug interaction of Calcium Disodium Edetate is with NA

  ►    Mechanism of Drug Drug Interaction :  , N.F.R.B
Ref :-   Book :    Page :    Edition : .  


►  Contraindication : Renal impairment, Hepatitis, Urinalysis
Ref :-   Book : Martindale    Page : 1574   Edition : 38.  
  ►  Mechanism of Action :   , N.F.R.B
Ref :-   Book :    Page :    Edition : .  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Garlic with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Allicin producse Chelation of lead --- ( Thuppil, V. (2013). REVIEW ARTICLE Treating Lead Toxicity: Possibilities beyond Synthetic Chelation. JKIMSU,, 2(1). )

  •   ►  URL --
  • http://www.jkimsu.com/jkimsu-vol2no1/jkimsu%20vol%202%20no%201%20jan%20-%20june%202013 .
  • %204-31.pdf .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal
    Ref :-   Book : Martindale    Page : 1574   Edition : 38.  

    ►    Plasma Half-life :   Min value :-   20 min,    Max value :-   60 min.  
    Ref :-   Book : Martindale    Page : 1574   Edition : 38.  

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA