Candesartan Cilexetil is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1331   Edition : 38,

  ►   Brandname : Candesar,Atacand,Amias,Candelong,Candesartan,Cantar,Ipsita,Candepressin

  ►  Strength : Tablet with 4  Mg, Tablet with 8  Mg, Tablet with 16  Mg, Tablet with 32  Mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 224   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1363   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 hypertension Oral 8 mg Tablet o.d.
2 Heart failure Oral 4 mg Tablet o.d.

Ref :-  Book : Martindale    Page : 1330   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 hypertension 1 Year 6 Year Oral 200 micrograms/kg Tablet
2 hypertension 6 Year 17 Year > 50 kg Oral 4 8 mg Tablet
3 hypertension 6 Year 17 Year < 50 kg Oral 8 16 mg Tablet

Ref :- Book : Martindale    Page : 1330   Edition : 38,
►  Side Effect : Dizziness, headache, Orthostatic hypotension, hyperkalaemia, myalgia, arthralgia, respiratory-tract disorders, back pain, gastrointestinal disturbance, fatigue, neutropenia, Rashes, Urticaria, pruritus, angioedema, raised liver enzyme values, rhabdomyolysis,
Ref :-   Book : Martindale    Page : 1330,1424   Edition : 38,

►  Drug Interaction : Drug interaction of Candesartan Cilexetil is with , Potassium -Sparing Diuretics , Angiotensin II Receptor Antagonist, ,  NA

  ►    Mechanism of Drug Drug Interaction :  An additive hyperkalaemic effect is possible with potassium supplements, potassium-sparing diuretics, Candesartan Cilexetil and some other angiotensin II receptor antagonists are metabolised by cytochrome P450 isoenzymes and interactions may occur with drugs that affect these enzymes.,
Ref :-   Book : Martindale    Page : 1330,1424   Edition : 38,


►  Contraindication : bilateral renal artery stenosis, pregnancy,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 350   Edition : 3,
  ►  Mechanism of Action :   Antagonize action of angiotensin ll at AT1 receptor may also indirectly increase vasorelaxant AT2 receptor activity. ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 350   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Pomegranate with same pathway,

  ►  Pathway with its reference as follows :-
  • angiotensin II receptor antagonist . --- (UH, J. & TH, G. (2012). Comparative Review on Harmless Herbs with Allopathic Remedies As AntiHypertensive. Research Journal Of Pharmaceutical, Biological And Chemical, 3(2), 673-687. )

  •   ►  URL -- http://www.rjpbcs.com/pdf/2012_3(2)/[80].pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Biliary, Renal,
    Ref :-   Book : Martindale    Page : 1363   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   9 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1363   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   3 hours,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 1363   Edition : 37,