Capecitabine is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 759   Edition : 38, Martindale    Page : 759   Edition : 38,

  ►   Brandname : Xeloda,Capecite,Capiibine,Capitabine

  ►  Strength : Tablet with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 759   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 756   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Colorectal cancer Oral 1.25 gm/m2 Tablet b.d.
2 Breast cancer Oral 1.25 gm/m2 Tablet b.d.
3 Gastric cancer Oral 0.8 1 gm/m2 Tablet b.d. For 14 days.

Ref :-  Book : Martindale    Page : 757   Edition : 38, Martindale    Page : 758   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : anorexia, nausea, stomatitis, diarrhea, Rashes, alopecia, erythema, dryness of the skin, pruritus, skin pigmentation disorders, nail disorders, Cardiotoxicity, bone marrow depression, paraesthesia, headache, Dizziness, insomnia, eyes irritation, hypercalcaemia, dehydration, encephalopathy, thromboembolism, Hyperbilirubinaemia,
Ref :-   Book : Martindale    Page : 756   Edition : 37, Martindale    Page : 758   Edition : 38,

►  Drug Interaction : Drug interaction of Capecitabine is with Antacid ,  Folinic acid (Leucovorin calcium), Warfarin , Sorivudine,
Ref :-   Book : Martindale    Page : 758   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Altered coagulation parameters and bleeding have occurred in patients on warfarin given capecitabine. Increased phenytoin plasma concentrations and symptoms of toxicity during use with capecitabine have been reported. Capecitabine must not be given with sorivudine or its analogues as fatal fluoropyrimidine toxicity may occur. Antacids containing aluminium or magnesium hydroxides cause a small increase in dose of capecitabine is reduced when it is given with either folinic acid. ,
Ref :-   Book : Martindale    Page : 758   Edition : 38,


►  Contraindication : Severe hepatic impairment, renal impairment,
Ref :-   Book : Martindale    Page : 758   Edition : 38,
  ►  Mechanism of Action :   Inhibits TS; incorporation of FUTP into RNA resulting in alteration in RNA processing; incorporation of FdUTP into DNA resulting in inhibition of DNA synthesis and function.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 959   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Cancer tree with Another pathway,

  ►  Pathway with its reference as follows :-
  • Camptotecin have anticancer effect. --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy, +C.+K.+Kokate, +A.P.+Purohit, +S.B.+Gokhale,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 759   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   1.5 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 759   Edition : 38,