Capreomycin is a Medicine belongs to Antimicrobial group whose information about Brand can be referenced from   Book : Martindale    Page : 231   Edition : 38,

  ►   Brandname : Capastat

  ►  Strength : Injection with 1  gm,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 848   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IM, IV,
Reference :-   Book : Martindale    Page : 231   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Tuberculosis IM or IV 1 gm Injection Daily for 2 to 4 months.

Ref :-  Book : Martindale    Page : 231   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Tuberculosis IM 15 30 mg/kg Injection

Ref :- Book : Martindale    Page : 231   Edition : 38,
►  Side Effect : transient proteinura, cylindruria, tinnitus, Deafness, eosinophilia, leucocytosis, leucopenia, Rashes, fever, Severe renal failure,
Ref :-   Book : Goodman    Page : 1563   Edition : 12,

►  Drug Interaction : Drug interaction of Capreomycin is with Neuromuscular blocker , Ototoxic Drugs, Nephrotoxic drugs,  NA

  ►    Mechanism of Drug Drug Interaction :  Care should be taken when capreomycin is used with other drugs that have neuromuscular blocking activity. It should not be given with other drugs that are ototoxic or nephrotoxic.,
Ref :-   Book : Martindale    Page : 231   Edition : 38,


►  Contraindication : renal impairment, Eighth cranial nerve damage,
Ref :-   Book : Martindale    Page : 231   Edition : 38,
  ►  Mechanism of Action :   It bind to specific 30S-subunit ribosomal proteins. Protein synthesis is inhibited by the drug in at least three ways : (1) interference with the initiation complex of peptide formation; (2) misreading of mRNA, which causes incorporation of incorrect amino acids into the peptide and results in a nonfunctional or toxic protein; and (3) breakup of polysomes into nonfunctional monosomes. These activities occur more or less simultaneously, and the overall effect is irreversible and lethal for the cell. Antimycobacterial activity is similar to that of aminoglycosides. ,
Ref :-   Book : Goodman    Page : 1563   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Barberry with Another pathway,

  ►  Pathway with its reference as follows :-
  • Barberry having active constituent act as antibiotic . --- (Karuppiah, P. & Rajaram, S. (2012). Antibacterial effect of Allium sativum cloves and Zingiber officinale rhizomes against multiple-drug resistant clinical pathogens. Asian Pacific Journal Of Tropical Biomedicine, 2(8), 597-601. doi:10.1016/s2221-1691(12)60104-x )

  •   ►  URL -- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609356/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 231   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 231   Edition : 38,