Captopril is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1332   Edition : 38,

  ►   Brandname : Acezide,Angiopril-DU,Capptril-H,Capozide

  ►  Strength : Tablet with 12.5  mg, Tablet with 25  mg, Tablet with 50  mg, Tablet with 100  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 190   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1365   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 hypertension Oral 12.5 mg Tablet b.d.
2 Heart failure Oral 6.25 12.5 mg Tablet
3 Myocardial infarction Oral 6.25 mg Tablet
4 Diabetic nephropathy Oral 75 100 mg Tablet Daily In divided oral doses.

Ref :-  Book : Martindale    Page : 1331   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Heart failure Oral 250 micrograms/kg
2 hypertension >1 Day >28 Day Oral 10 50 micrograms/kg
3 Heart failure or Proteinuria in nephritis >1 Day >28 Day Oral 10 50 micrograms/kg
4 Heart failure or Proteinuria in nephritis 1 Month 12 Year Oral 100 micrograms/kg
5 Heart failure or Proteinuria in nephritis 12 Year 18 Year Oral 100 micrograms/kg
6 hypertension 1 Month 12 Year Oral 100 micrograms/kg
7 hypertension 12 Year 18 Year Oral 100 micrograms/kg

Ref :- Book : Martindale    Page : 1365   Edition : 37,
Precaution :- If a Patient is using 'Captopril' drug in  Cardiac Disease  disease, then Please contraindicated in pregnancy .

►  Side Effect : taste disturbances, Skin rashes, hypotension, Dizziness, fatigue, headache, nausea, gastrointestinal disturbance, persistent dry cough, upper respiratory-tract infections, angioedema, erythema multiforme, toxic epidermal necrolysis, photosensitivity, alopecia, hypersensitivity reactions, neutropenia, agranulocytosis, renal failure, thrombocytopenia, stomatitis, abdominal pain, Pancreatitis, hepatocellular injury, cholestatic jaundice, muscle cramp, paraesthesia, mood sleep disturbances, impotence,
Ref :-   Book : Martindale    Page : 1330,1285   Edition : 38,

►  Drug Interaction : Drug interaction of Captopril is with Diuretic Agents , Antihypertensive Agents , Alcohol, Potassium -Sparing Diuretics , NSAIDS,  Indomethacin ,
Ref :-   Book : Martindale    Page : 1332,1288   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Excessive hypotension may occur when Captopril are used with diuretics, other antihypertensives, or other agents, including alcohol, that lower blood pressure. An additive hyperkalaemic effect is possible in patients receiving Captopril with potassium sparing diuretics, potassium supplements (including potassium-containing salt substitutes), or other drugs that can cause hyperkalaemia (such as indometacin) and serum-potassium concentrations should be monitored. The adverse effects of Captopril on the kidneys may be potentiated by other drugs, such as NSAIDs, that can affect renal function. ,
Ref :-   Book : Martindale    Page : 1332,1288   Edition : 38,


►  Contraindication : Acute renal failure, Pregnancy, Renal artery stenosis, Angioedema,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 349   Edition : 3,
  ►  Mechanism of Action :   Inhibition of ACE decreases conversion of angiotensin (AT) I to (AT) II, and thereby decreases arteriolar vasoconstriction, aldosterone synthesis, renal proximal tubule NaCl reabsorption, and ADH release. ACE inhibitors also inhibit the degradation of bradykinin, and thereby increase vasodilation.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 349   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- beetroot with Another pathway, Achillea fragrantissima with same pathway, Rhazya stricta with same pathway, Moringa peregrina with same pathway, Chia seed with same pathway,

  ►  Pathway with its reference as follows :-
  • Vasodilator. --- ( Clifford, T., Howatson, G., West, D., & Stevenson, E. (2015). The Potential Benefits of Red Beetroot Supplementation in Health and Disease. Nutrients, 7(4), 2801-2822. )
  • Achillea fragratissima act as ACE inhibitor . --- (Fahad, M. (2017). Journal Of Medicinal Plants Research., 10(8), 93-99. http://dx.doi.org/10.5897/JMPR2015.6043 )
  • Rhazya stricta act as ACE inhibitor . --- (Fahad, M. (2017). Journal Of Medicinal Plants Research., 10(8), 93-99. http://dx.doi.org/10.5897/JMPR2015.6043 )
  • Moringa peregrina act as ACE inhibitor --- (Fahad, M. (2017). Journal Of Medicinal Plants Research., 10(8), 93-99. http://dx.doi.org/10.5897/JMPR2015.6043 )
  • Act as ace inhibitor --- (Ullah R. Nutritional and therapeutic perspectives of Chia (Salvia hispanica L.): a review. J Food Sci Technol. 2016;53(4). )

  •   ►  URL -- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425174/, http://www.academicjournals.org/journal/JMPR/article-abstract/3FB279457381, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926888/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- IRON with Dietary Substance is Drug Enhancer, POTASSIUM with Dietary Substance is Drug Inhibitor, ZINC with Decrease in Nutrient Level,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- POTASSIUM with Increase the risk of hyperkalemia ., CAPSICUM with Cause risk of cough ,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Mohan, L. (2013). Antihypertensive Drugs Interaction with Herbal Medicine – Review. International Journal Of Pharmaceutical And Phytopharmacological Research (Eijppr), 3(2), 139-143.

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20, http://eijppr.com/vol3-issue2/eIJPPR-2013-3-2-139-143.pdf,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 1365   Edition : 37,


    ►    Plasma Half-life :   Min value :-   2 hours,    Max value :-   3 hours,
    Ref :-   Book : Martindale    Page : 1365   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   1 hour,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1365   Edition : 37,