Carbamazapine is a Medicine belongs to Antiepileptics group whose information about Brand can be referenced from   Book : Martindale    Page : 520   Edition : 37, Martindale    Page : 518   Edition : 38,

  ►   Brandname : Cizetol,Tegretol,carbatrol,Deleptin,Li-Zhen,Carba,Acetol,Antilep,Carbagen

  ►  Strength : Tablet with 100  Mg, Tablet with 200  Mg, Capsule with 200  Mg, Capsule with 300  Mg, Tablet (Extended Release Tablets) with 100  mg, Tablet (Extended Release Tablets) with 200  mg, Tablet (Extended Release Tablets) with 400  mg, Suspension with 100  mg/5mL,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 427   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 518   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Epilepsy Oral 100 200 mg o.d/b.d
2 TRIGEMINAL NEURALGIA Oral 100 mg b.d.
3 Bipolar disorder Oral 400 mg Daily in divided doses,

Ref :-  Book : Martindale    Page : 512   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Generalised tonic clonic and partial seizures Oral 10 20 mg/kg Tablet/Capsule
2 Generalised tonic clonic and partial seizures 1 Year Oral 100 200 mg Tablet/Capsule
3 Generalised tonic clonic and partial seizures 1 Year 5 Year Oral 200 400 mg Tablet/Capsule
4 Generalised tonic clonic and partial seizures 5 Year 10 Year Oral 400 600 mg Tablet/Capsule
5 Generalised tonic clonic and partial seizures 10 Year 15 Year Oral 0.6 1 gm Tablet/Capsule
6 Generalised tonic clonic and partial seizures 1 Month 12 Year Oral 5 mg/kg Tablet/Capsule h.s.

Ref :- Book : Martindale    Page : 513   Edition : 38,
Precaution :- If a Patient is using 'Carbamazapine' drug in  Childhood absence epilepsy  disease, then Please induceabsenceseizures .

Precaution :- If a Patient is using 'Carbamazapine' drug in  Acute Intermittent Porphyria  disease, then Please Do not use .

Precaution :- If a Patient is using 'Carbamazapine' drug in ACUTE VIRAL HEPATITIS disease, then Please use with caution   if he ever suffered from Epilapsy disease.
Precaution :- If a Patient is using 'Carbamazapine' drug in ACUTE VIRAL HEPATITIS disease, then Please use with caution   if he ever suffered from Seizure disease.
►  Side Effect : Dizziness, drowsiness, ataxia, gastrointestinal disturbance, nausea, vomiting, Skin reactions, nystagmus, diplopia, photosensitivity reactions, Urticaria, alopecia, exfoliative dermatitis, toxic epidermal necrolysis, erythema multiforme, Stevens-Johnson syndrome, dry mouth, abdominal pain, anorexia, diarrhea, constipation, hyponatraemia, paraesthesia, headache, arrhythmia, heart block, heart failure, impotence, male infertility, Gynaecomastia, galactorrhoea, dystonia, dyskinesia, asterixis, stupor, coma, convulsion, respiratory depression, death, agranulocytosis, aplastic anaemia, eosinophilia, leucopenia, leucocytosis, thrombocytopenia, purpura, lymphadenopathy, splenomegaly, pneumonitis, hepatitis, cholestatic jaundice, oedema, erythematous rashes, exacerbate seizures,
Ref :-   Book : Martindale    Page : 514   Edition : 37,

►  Drug Interaction : Drug interaction of Carbamazapine is with Phenobarbital , Valproic acid(sodium valproate), Phenytoin , Haloperidol , Lamotrigine , Fluoxetine , Topiramate , Isoniazid , Cimetidine , Erythromycin , Tiagabine,
Ref :-   Book : Goodman    Page : 595   Edition : 12,


  ►    Mechanism of Drug Drug Interaction :  Phenobarbital, phenytoin, and valproate may increase the metabolism of carbamazepine by inducing CYP3A4; carbamazepine may enhance the biotransformation of phenytoin. Concurrent administration of carbamazepine may lower concentrations of valproate, lamotrigine, tiagabine, and topiramate. Carbamazepine reduces both the plasma concentration and therapeutic effect of haloperidol. The metabolism of carbamazepine may be inhibited by propoxyphene, erythromycin, cimetidine, fluoxetine, and isoniazid.,
Ref :-   Book : Goodman    Page : 595   Edition : 12,


►  Contraindication : AV block, bone marrow depression,
Ref :-   Book : Martindale    Page : 514,515   Edition : 38,
  ►  Mechanism of Action :   Carbamazepine, blocks Na + channels at therapeutic concentrations and inhibits high-frequency repetitive firing in neurons in culture. It also acts presynaptically to decrease synaptic transmission.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 409   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Valerian with Another pathway,

  ►  Pathway with its reference as follows :-
  • Valeremic acid have Anticonvulsant activity --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- BIOTIN with Increase in Nutrient Level, FOLATE with Increase in Nutrient Level, VITAMIN B12 with Increase in Nutrient Level, ST JOHNS WORT with Dietary Substance is Drug Enhancer,

      ►  Reference :-
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf, https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- 5 HTP(5-HYDROXYTRYPTOPHAN) with Cause anxiety,confusion & other side effect ., IODINE with Increase side effect , FOLIC ACID with Interect with anticonvulsins, FOLIC ACID with Interect with anticonvulsins,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,

    ►   Route of Elimination :   Fecal, Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 518   Edition : 37,


    ►    Plasma Half-life :   Min value :-   12 hours,    Max value :-   24 hours,
    Ref :-   Book : Martindale    Page : 518   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   4 hours,    Max value :-   8 hours,
    Ref :-   Book : Goodman    Page : 595   Edition : 12,