Carmustine is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 762   Edition : 38,

  ►   Brandname : BiCNU; Gliadel; Carmubrist

  ►  Strength : Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 761   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV,
Reference :-   Book : Martindale    Page : 760   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Hodgkin’s lymphomas IV infusion 150 200 mg/m2 Injection Single dose.
2 Non Hodgkin’s lymphoma IV infusion 150 200 mg/m2 Injection Single dose.

Ref :-  Book : Martindale    Page : 760   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : vomiting, convulsion, Flushing of the skin, hypotension, tachycardia, chest pain, headache, hypersensitivity reactions, bone marrow depression, nausea, convulsion, Cerebral oedema, suffusion of conjunctiva, leucopenia, thrombocytopenia, pulmonary fibrosis, renal damage, Hepatic damage, Neuroretinitis,
Ref :-   Book : Martindale    Page : 760   Edition : 37, Martindale    Page : 761   Edition : 38,

►  Drug Interaction : Drug interaction of Carmustine is with Live Vaccines, ,  NA

  ►    Mechanism of Drug Drug Interaction :  Because of their effects on the gastrointestinal mucosa antineoplastics have the potential to interfere with the absorption of drugs given orally Antineoplastics that have an immunosuppressant effect may reduce the response to vaccines, and there is a possibility of generalised infection with live vaccines. Use with live vaccines should generally be avoided. Many antineoplastics are inhibitors of certain isoenzymes of cytochrome P450 and some antineoplastics are also metabolised by these enzymes.,
Ref :-   Book : Martindale    Page : 762,733   Edition : 38,


►  Contraindication : Children with risk of severe delayed pulmonary toxicity, reduced lung function,
Ref :-   Book : Martindale    Page : 762   Edition : 38,
  ►  Mechanism of Action :   Forms DNA cross-links, resulting in inhibition of DNA synthesis and function.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 956   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Vinca with Another pathway,

  ►  Pathway with its reference as follows :-
  • Anti-cancer --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- MAGNESIUM with Decrease in Nutrient Level, POTASSIUM with Decrease in Nutrient Level,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- with It decrease the kidney and bladder toxicity of the chemotherapy drug ., GLUTAMINE with Though cancer cells use glutamine as a fuel source , So supplement glutamin with diet it reduced side effect of drug mouth sores .,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,

    ►   Route of Elimination :   Renal, lungs,
    Ref :-   Book : Martindale    Page : 762   Edition : 38,


    ►    Plasma Half-life :   Min value :-   15 min,    Max value :-   90 min,
    Ref :-   Book : Goodman    Page : 1686   Edition : 12,


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA