Carvedilol is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1366   Edition : 37, Martindale    Page : 1334   Edition : 38, Martindale    Page : 1334   Edition : 38,

  ►   Brandname : Carloc,Carvil,Carvas; Carvedil; Carvidol; CarLich; Carvedilen; Coreg,Eucardic,Cardivas

  ►  Strength : Tablet with 3.125  mg, Tablet with 6.25  mg, Tablet with 12.5  mg, Tablet with 25  mg, Capsule with 10  mg, Capsule with 20  mg, Capsule with 40  mg, Capsule with 80  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 166   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1367   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 hypertension Oral 12.5 mg Tablet/Capsule o.d.
2 Angina pectoris Oral 12.5 mg Tablet/Capsule b.d.
3 Heart failure Oral 3.125 mg Tablet/Capsule b.d.
4 Left ventricular dysfunction after myocardial infarction Oral 6.25 mg Tablet/Capsule b.d.

Ref :-  Book : Martindale    Page : 1367   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Heart failure 2 Year 18 Year Oral 50 micrograms Tablet/Capsule b.d.

Ref :- Book : Martindale    Page : 1367   Edition : 37,
►  Side Effect : hallucinations, Confusion, amnesia, Sleep disturbances, nightmares, coma, convulsion, fatigue, muscle cramp, nausea, vomiting, diarrhea, constipation, abdominal cramping, Skin rashes, pruritus, exacerbation of psoriasis, excess sweating, reversible alopecia, Decreased tear production, Blurred Vision, conjunctivitis, nonthrombocytopenic purpura, thrombocytopenia, soreness, dry mouth, raised liver enzymes, male impotence, sclerosing peritonitis, retroperitoneal fibrosis, Liver function abnormalities, heart failure, heart block, bronchospasm, bradycardia, hypotension, paraesthesia, arthralgia, myopathies,
Ref :-   Book : Martindale    Page : 1349, 1366   Edition : 37, Martindale    Page : 1333,1319   Edition : 38,

►  Drug Interaction : Drug interaction of Carvedilol is with Calcium Channel Blockers , NSAIDS, General anaesthetics , Antiarrhythmics, Angiotensin converting enzyme inhibitor,  Digoxin , Aldesleukin , Verapamil , Sotalol ,
Ref :-   Book : Martindale    Page : 1334,1321   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Drugs that enhance the antihypertensive effects of beta blockers, such as ACE inhibitors, calcium-channel blockers, and clonidine may be useful in controlling hypertension. Drugs that cause hypotension such as aldesleukin and general anaesthetics also enhance the antihypertensive effects of beta blockers while other drugs, for example NSAIDs, antagonise the antihypertensive effects. Use of beta blockers with other cardiac depressants such as antiarrhythmics and rate-limiting calcium channel blockers can precipitate bradycardia and heart block; the combination of intravenous verapamil and beta blockers should especially be avoided. Sotalol is particularly prone to interactions with other drugs affecting cardiac conduction. Beta blockers may potentiate bradycardia due to digoxin. ,
Ref :-   Book : Martindale    Page : 1334,1321   Edition : 38,


►  Contraindication : hepatic impairment, renal impairment,
Ref :-   Book : Martindale    Page : 1366   Edition : 37,
  ►  Mechanism of Action :   Block β-adrenergic receptors.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 146   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Coriander seeds with Another pathway,

  ►  Pathway with its reference as follows :-
  • Coriandrol increased degradation of cholesterol to fecal bile acids and neutral eterols appeared to account for its hypocholesterolemic --- (Dhanapakiam1, P. (2008). The cholesterol lowering property of coriander seeds (Coriandrum sativum): Mechanism of action. Journal Of Environmental Biology, 29(1). )

  •   ►  URL -- http://www.jeb.co.in/journal_issues/200801_jan08/paper_08.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Hepatic (Metabolism), Biliary,
    Ref :-   Book : Martindale    Page : 1334   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   6 hours,    Max value :-   10 hours,
    Ref :-   Book : Martindale    Page : 1334   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   2 hours,
    Ref :-   Book : Martindale    Page : 1334   Edition : 38,