Cefaclor is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 233   Edition : 38,

  ►   Brandname : Halocef,Keflor,Bacticlor,Raniclor; Beinuoke; Ceclor; Ceclorbeta; Acticlor

  ►  Strength : Capsule with 250  mg, Capsule with 500  mg, Tablet (Extended Release Tablets) with 375  mg, Tablet (Extended Release Tablets) with 500  mg, Suspension with 125/5  mg/ml, Suspension with 187/5  mg/ml, Suspension with 250/5  mg/ml, Suspension with 375/5  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 807   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 232   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Gram positive and gram negative bacterial infections Oral 250 500 mg Tablet/Capsule t.i.d.

Ref :-  Book : Martindale    Page : 232   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Cystic fibrosis 1 Month 1 Year Oral 125 mg Tablet/Capsule t.i.d.
2 Cystic fibrosis 1 Year 7 Year Oral 250 mg Tablet/Capsule t.i.d.
3 Cystic fibrosis more than 7 Year Oral 500 mg Tablet/Capsule t.i.d.
4 Mild to moderate infections more than 1 Month Oral 20 40 mg/kg Tablet/Capsule
5 Mild to moderate infections 1 Month 1 Year Oral 62.5 mg Tablet/Capsule t.i.d.
6 Mild to moderate infections 1 Year 5 Year Oral 125 mg Tablet/Capsule t.i.d.
7 Mild to moderate infections more than 5 Year Oral 250 mg Tablet/Capsule t.i.d.

Ref :- Book : Martindale    Page : 232   Edition : 38, Martindale    Page : 233   Edition : 38,
►  Side Effect : thrombophlebitis, Platelet dysfunction, Bleeding complications, anaphylaxis, fever, eosinophilia, Urticaria, Skin rashes,
Ref :-   Book : Martindale    Page : 233, 234, 235    Edition : 38, Martindale    Page : 232, 234,235   Edition : 38,

►  Drug Interaction : Drug interaction of Cefaclor is with Probenecid ,
Ref :-   Book : Martindale    Page : 233,234   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  The renal excretion of Cefaclor and many other cephalosporins is delayed by probenecid. ,
Ref :-   Book : Martindale    Page : 233,234   Edition : 38,


►  Contraindication : hypersensitive to other cephalosporins, penicillin-sensitive patient, renal impairment,
Ref :-   Book : Martindale    Page : 233, 234, 235    Edition : 38,
  ►  Mechanism of Action :   Cefaclor inhibits the bacterial growth by interfering with the transpeptidation reaction of bacterial cell wall synthesis. Cefaclor is a structural analog of the natural D-Ala-D-Ala substrate, covalently bind to the active site of PBPs. This inhibits the transpeptidation reaction, halting peptidoglycan synthesis, and the cell dies.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 792   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Tulsi with Another pathway,

  ►  Pathway with its reference as follows :-
  • Antibiotic effect . --- ( "Queen Of Herbs Tulsi (Ocimum Sanctum) Removes Impurities From Water And Plays Disinfectant Role". Journal of Medicinal Plants Studies 2.2 (2014): 1-8. Print. )

  •   ►  URL -- http://www.plantsjournal.com/vol2Issue2/Issue_feb_2014/1.3.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- VITAMIN K with Decrease in Nutrient Level, PROBIOTICS with Decrease in Nutrient Level,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 236   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   0.5 hours,    Max value :-   1 hours,
    Ref :-   Book : Martindale    Page : 236   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   0.5 hours,    Max value :-   1 hours,
    Ref :-   Book : Martindale    Page : 236   Edition : 37,