Cefazolin is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 238   Edition : 38  

  ►   Brandname : Azolin, Reflin; Basocef; Cefadin; Ciprid; Orizplin
  ►  Strength : Injection with

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 807   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IM, IV, intra-peritoneal,, intra-ocular injection
Reference :-   Book : Martindale    Page : 237   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Susceptible bacterial infections IM or IV 0.25 1 gm Injection t.i.d/q.i.d
2 Life-threatening infections IM or IV 1 1.5 gm Injection q.i.d.
3 Prophylaxis of infection IM or IV 1 gm Injection Half to one hour before the operation.

Ref :-  Book : Martindale    Page : 237   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Susceptible bacterial infections more than 1 Month IM or IV 25 50 mg/kg Injection
2 SEVERE INFECTION over 1 Month i.v/i.m 100 mg/kg Injection

Ref :- Book : Martindale    Page : 238   Edition : 38  
►  Side Effect : Hypersenstivity, Hypoprothrombinaemia, Platelet dysfunction, Stevens-Johnson syndrome, Convulsion, CNS toxicity, Pain at the sites of i.v. or i.m. injection
Ref :-   Book : Martindale    Page : 238, 235   Edition : 38.   Martindale    Page : 235, 238   Edition : 38.   Martindale    Page : 238,235   Edition : 38.  

►  Drug Interaction : Drug interaction of Cefazolin is with Alcohol,  Probenecid , Warfarin
Ref :-   Book : Martindale    Page : 238   Edition : 37.   Martindale    Page : 238,235   Edition : 38.  


  ►    Mechanism of Drug Drug Interaction :  Probenecid delayes renal excretion of Cefazolin. Cefazolin contains a methylthiadiazolethiol sidechain; like cephalosporins containing the related Nmethylthiotetrazole side-chain, it may have the potential to cause a disulfiram like reaction with alcohol, and enhance the effects of warfarin
Ref :-   Book : Martindale    Page : 238   Edition : 38.  


►  Contraindication : Hypersensitive to other cephalosporins, Renal impairment, Penicillin-sensitive patient
Ref :-   Book : Martindale    Page : 238,235   Edition : 38.  
  ►  Mechanism of Action :   Cefazolin inhibits the bacterial growth by interfearing with the transpeptidation reaction of bacterial cell wall synthesis. Cefazolin is a structural analog of the natural D-Ala-D-Ala substrate, covalently bind to the active site of PBPs. This inhibits the transpeptidation reaction, halting peptidoglycan synthesis, and the cell dies.
Ref :-   Book : Basic & Clinical pharmacology    Page : 792   Edition : 12.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Turmeric with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Antibiotic effect . --- ( Zorofchian Moghadamtousi, Soheil et al. "A Review On Antibacterial, Antiviral, And Antifungal Activity Of Curcumin". BioMed Research International 2014 (2014): 1-12. Web. )

  •   ►  URL --
  • https://www.hindawi.com/journals/bmri/2014/186864/ .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- PROBIOTICS with Decrease in Nutrient Level.   VITAMIN K with Decrease in Nutrient Level.  

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf


    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Biliary, Renal
    Ref :-   Book : Martindale    Page : 238   Edition : 38.  

    ►    Plasma Half-life :   Min value :-   1.8 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 238   Edition : 38.  

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 238   Edition : 38.