Cefdinir is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 239   Edition : 38,

  ►   Brandname :
Kefnir; Cefzon; Adcef; Adinir; Aldinir; Omnicef


  ►  Strength :
Capsule with 300  Mg, Suspension with 125/5  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 807   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration :
Oral,
Reference :-   Book : Martindale    Page : 242   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 SEVERE INFECTION Oral 600 mg Capsule o.d.
2 SEVERE INFECTION Oral 300 mg Capsule b.d.
3 Skin infections Oral 600 mg Capsule As a single dose.
4 Pneumonia Oral 600 mg Capsule As a single dose.

Ref :-  Book : Goodman    Page : 1495   Edition : 12, Martindale    Page : 238   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Susceptible bacterial infections 6 Month Oral 14 mg/kg Capsule

Ref :- Book : Martindale    Page : 238   Edition : 38,
►  Side Effect :
gastrointestinal disturbance, hypersensitivity reactions, convulsion, CNS toxicity, , Skin rashes, Urticaria, eosinophilia, fever, Platelet dysfunction,
Ref :-   Book : Martindale    Page : 238,235   Edition : 38,
►  Drug Interaction : Drug interaction of Cefdinir is with
Antacid ,  Iron , Probenecid ,
Ref :-   Book : Martindale    Page : 239   Edition : 38,

  ►    Mechanism of Drug Drug Interaction : 
Absorption of cefdinir is decreased by antacids or iron supplements and doses should be separated by an interval of at least 2 hours. Probenecid reduces the renal excretion of cefdinir.,
Ref :-   Book : Martindale    Page : 239   Edition : 38,

►  Contraindication :
hypersensitive to other cephalosporins, renal impairment, penicillin-sensitive patient,
Ref :-   Book : Martindale    Page : 238,235   Edition : 38,
  ►  Mechanism of Action :  
Cefdinir inhibits the bacterial growth by interfearing with the transpeptidation reaction of bacterial cell wall synthesis. Cefdinir is a structural analog of the natural D-Ala-D-Ala substrate, covalently bind to the active site of PBPs. This inhibits the transpeptidation reaction, halting peptidoglycan synthesis, and the cell dies. ,
Ref :-   Book : Basic & Clinical pharmacology    Page : 792   Edition : 12,

Pathway of Dietry Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- Tulsi with Another pathway,

  ►  Pathway with its reference as follows :-
  • Antibiotic effect . --- (Kayastha, Babita Labh. "Queen Of Herbs Tulsi (Ocimum Sanctum) Removes Impurities From Water And Plays Disinfectant Role". Journal of Medicinal Plants Studies 2.2 (2014): 1-8. Print. )

    •   ►  URL -- http://www.plantsjournal.com/vol2Issue2/Issue_feb_2014/1.3.pdf,


    Dietry Substance Interactions

    ​   ► This Medicine interact with :- PROBIOTICS with Decrease in Nutrient Level, VITAMIN K with Decrease in Nutrient Level,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

    •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,


    ContraIndication Dietry Substance

    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :  
    Renal,
    Ref :-   Book : Martindale    Page : 239   Edition : 38,

    ►    Plasma Half-life :      
    Min value :-   1.7 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 239   Edition : 38,

    ►    Peak Plasma Concentration :  
    Min value :-   2 hours,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 239   Edition : 38,