Cefepime Hydrochloride is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 240   Edition : 38  

  ►   Brandname : Biopime, Ceficad, Maxipime; Bo Shuai; Bo Zhi; Adpime
  ►  Strength : Injection with 0.5 gm.  Injection with 1 gm.  Injection with 2 gm. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 807   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IM, IV
Reference :-   Book : Martindale    Page : 239   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Mild to moderate infections IV infusion 1 2 gm Injection Daily in 2 divided dose, over at least 30 min.
2 Mild to moderate infections IM 1 2 gm Injection Daily in two divided dose, over at least 30 min.
3 Severe infections IV infusion 4 gm Injection Daily in two divided dose.
4 Severe infections IM up to 4 gm Injection Daily in two divided dose.
5 Dosing in Obesity: Modest dose increase : 2gm IV q8h instead of the usual q24h. Ref; The Sanford Guide To Antimicrobial Therapy, pg 231, ed 47

Ref :-  Book : Martindale    Page : 239   Edition : 38      Page :    Edition :   



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Susceptible bacterial infections less than 1Day less than 28Day IV infusion 30 mg/kg Injection b.d.
2 Susceptible bacterial infections less than 1 Day less than 28 Day IM 30 mg/kg Injection b.d.

Ref :- Book : Martindale    Page : 239   Edition : 38  
Precaution :- If a Patient is using 'Cefepime Hydrochloride' drug in  autoimmune hemolytic anemia  disease, then Please Avoid .

►  Side Effect : Gastrointestinal disturbance, Hypersensitivity reactions, Thrombophlebitis, Convulsion, CNS toxicity, Fever
Ref :-   Book : Martindale    Page : 235, 240   Edition : 38.   Martindale    Page : 240,235   Edition : 38.  

►  Drug Interaction : Drug interaction of Cefepime Hydrochloride is with NA

  ►    Mechanism of Drug Drug Interaction : 
Ref :-   Book :    Page :    Edition : .  


►  Contraindication : Hypersensitive to other cephalosporins, Renal impairment, Penicillin-sensitive patient
Ref :-   Book : Martindale    Page : 240,235   Edition : 38.  
  ►  Mechanism of Action :   Cefepime Hydrochloride inhibits the bacterial growth by interfearing with the transpeptidation reaction of bacterial cell wall synthesis. Cefdinir is a structural analog of the natural D-Ala-D-Ala substrate, covalently bind to the active site of PBPs. This inhibits the transpeptidation reaction, halting peptidoglycan synthesis, and the cell dies.
Ref :-   Book : Basic & Clinical pharmacology    Page : 792   Edition : 12.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Tulsi with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Antibiotic effect . --- (Kayastha, Babita Labh. "Queen Of Herbs Tulsi (Ocimum Sanctum) Removes Impurities From Water And Plays Disinfectant Role". Journal of Medicinal Plants Studies 2.2 (2014): 1-8. Print. )

  •   ►  URL --
  • http://www.plantsjournal.com/vol2Issue2/Issue_feb_2014/1.3.pdf .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- IRON with Dietary Substance is Drug Inhibitor.   PROBIOTICS with Decrease in Nutrient Level.  

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20
    http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf


    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal
    Ref :-   Book : Martindale    Page : 240   Edition : 38.  

    ►    Plasma Half-life :   Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 240   Edition : 38.  

    ►    Peak Plasma Concentration :   Min value :-   1.5 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 240   Edition : 38.