Cefoperazone is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 243   Edition : 38,

  ►   Brandname : Cefaking,Cefina; Cefobid; Da Nuo Xin; Cefpar; Ceprazo; Cizon

  ►  Strength : Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 243   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, IM,
Reference :-   Book : Martindale    Page : 243   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Susceptible bacterial infections IM or IV 2 4 gm Injection Daily in 2 divided doses.
2 Severe infections IM or IV 12 gm Injection Daily in 2 to 4 divided doses.

Ref :-  Book : Martindale    Page : 243   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Gram negative and gram positive pathogens less than 1 Day less than 28 Day IM or IV 100 mg/kg/day Injection
2 Gram negative and gram positive pathogens IM or IV 100 150 mg/kg/day Injection

Ref :- Book : Nelson's textbook of Pediatrics    Page : 903   Edition : 19,
►  Side Effect : gastrointestinal disturbance, hypersensitivity reactions, promoting colonisation with resistant organism, hypoprothrombinaemia, convulsion, CNS toxicity, bleeding, eosinophilia, fever,
Ref :-   Book : Martindale    Page : 235, 243   Edition : 38, Martindale    Page : 243,235   Edition : 38,

►  Drug Interaction : Drug interaction of Cefoperazone is with Alcohol, Anticoagulant ,  NA

  ►    Mechanism of Drug Drug Interaction :  A disulfiram-like interaction with alcohol may occur. Cefoperazone may enhance the hypoprothrombinaemic response to anticoagulants.,
Ref :-   Book : Martindale    Page : 236,243   Edition : 38,


►  Contraindication : hypersensitive to penicillins, hypersensitive to other cephalosporins, renal impairment,
Ref :-   Book : Martindale    Page : 235, 243   Edition : 38, Martindale    Page : 243,235   Edition : 38,
  ►  Mechanism of Action :   Cefoperazone inhibits the bacterial growth by interfearing with the transpeptidation reaction of bacterial cell wall synthesis. Cefoperazone is a structural analog of the natural D-Ala-D-Ala substrate, covalently bind to the active site of PBPs. This inhibits the transpeptidation reaction, halting peptidoglycan synthesis, and the cell dies.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 792   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Red algae with Another pathway,

  ►  Pathway with its reference as follows :-
  • Antibiotic effect --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- CINNAMON with Increased risk of hypoglycaemia, bleeding ,

      ►  Reference :-
  • Posadzki, P., Watson, L., & Ernst, E. (2012). Herb-drug interactions: an overview of systematic reviews. British Journal Of Clinical Pharmacology, no-no. http://dx.doi.org/10.1111/j.1365-2125.2012.04350.x

  •   ►  URL -- http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2012.04350.x/full,

    ►   Route of Elimination :   Biliary, Renal,
    Ref :-   Book : Martindale    Page : 246   Edition : 38,


    ►    Plasma Half-life :   Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 246   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   2 hours,
    Ref :-   Book : Martindale    Page : 246   Edition : 37,