Cefotaxime is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 245   Edition : 38,

  ►   Brandname : Amtaxime,Biotax,Claforan; Dalilong; Haltax; Axiom

  ►  Strength : Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 807   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IM, IV,
Reference :-   Book : Martindale    Page : 244   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Mild to moderate infections i.v/i.m 1 gm Injection b.d.
2 Moderate to severe infection i.v/i.m 1 2 gm Injection t.i.d.
3 Septicaemia i.v/i.m 6 8 gm Injection daily in 3 to 4 divided doses
4 Pseudomonal infections i.v/i.m <6 gm Injection o.d.
5 Surgical infection prophylaxis i.v/i.m 1 gm Injection given 30 to 90 minutes before surgery.
6 Gonorrhoea i.v/i.m 0.5 gm Injection Aa a single dose.
7 Gonorrhoea i.v/i.m 1 gm Injection Aa a single dose.

Ref :-  Book : Martindale    Page : 244   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Meningitis less than 1 Day less than 7 Day IM or IV 25 mg/kg Injection b.d.
2 Meningitis 7 Day 21 Day i.v/i.m 25 mg/kg Injection t.i.d.
3 Meningitis 21 Day 28 Day IM or IV 25 mg/kg Injection t.i.d/q.i.d
4 Meningitis 1 Month more than 1 Month IM or IV 50 mg/kg Injection b.d/t.i.d
5 SEVERE INFECTION under 7 days IM or IV 25 mg/kg Injection b.d.
6 SEVERE INFECTION 7 Day 21 Day IM or IV 25 mg/kg Injection t.i.d.
7 SEVERE INFECTION 21 Day 28 Day IM or IV 25 mg/kg Injection t.i.d/q.i.d
8 SEVERE INFECTION 1 Month more than 1 month IM or IV 50 mg/kg Injection b.d/t.i.d

Ref :- Book : Martindale    Page : 244   Edition : 38,
Precaution :- If a Patient is using 'Cefotaxime' drug in  auto immune hemolytic anemia  disease, then Please Avoid .

►  Side Effect : gastrointestinal disturbance, hypersensitivity reactions, arrhythmia, convulsion, CNS toxicity, fever, Urticaria, Platelet dysfunction, Bleeding complications,
Ref :-   Book : Martindale    Page : 235, 244   Edition : 38, Martindale    Page : 244,235   Edition : 38,

►  Drug Interaction : Drug interaction of Cefotaxime is with Probenecid ,
Ref :-   Book : Martindale    Page : 235, 244   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Probenecid reduces the renal clearance of cefotaxime, resulting in higher and prolonged plasma concentrations of cefotaxime .,
Ref :-   Book : Martindale    Page : 235,244   Edition : 38,


►  Contraindication : renal impairment, hypersensitive to other cephalosporins, penicillin-sensitive patient,
Ref :-   Book : Martindale    Page : 244,235   Edition : 38,
  ►  Mechanism of Action :   It inhibits the bacterial growth by interfearing with the transpeptidation reaction of bacterial cell wall synthesis. Cefotaxime is a structural analog of the natural D-Ala-D-Ala substrate, covalently bind to the active site of PBPs. This inhibits the transpeptidation reaction, halting peptidoglycan synthesis, and the cell dies.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 792   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Eucalyptus oil with Another pathway,

  ►  Pathway with its reference as follows :-
  • antibiotic property --- (Kokate, C.K. and A.p. Purohit. Pharmacognosy. Nirali prakashan: Chennai, 2013. Print. )

  •   ►  URL -- https://books.google.co.in/books?id=KwYIsLRyDp4C&pg=SL1-PA47&dq=Kokate, +C.K.+Pharmaco,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Biliary, Fecal, Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 245   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   1 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 248   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   30 min,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 245   Edition : 38,