Cefotetan is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 245   Edition : 38,

  ►   Brandname : Cefotan.

  ►  Strength : Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 807   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, IM,
Reference :-   Book : Martindale    Page : 245   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Life-threatening infections IV 3 gm Injection b.d.
2 Infection prophylaxis during surgical procedures IV 1 gm Injection 30 to 60 minutes before surgery
3 Pelvic Inflammatory Disease IV 2 gm Injection b.d.

Ref :-  Book : Martindale    Page : 245   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Streptococcal endocarditis. IM 40 80 mg/kg Injection
2 Pelvic Inflammatory Disease IV 2 gm Injection b.d.
3 Streptococcal endocarditis. IV 40 80 mg/kg/day Injection

Ref :- Book : Nelson's textbook of Pediatrics    Page : 903   Edition : 19,
►  Side Effect : gastrointestinal disturbance, hypersensitivity reactions, bleeding, convulsion, CNS toxicity, fever, Bleeding complications, Urticaria, Platelet dysfunction,
Ref :-   Book : Martindale    Page : 246,236   Edition : 38,

►  Drug Interaction : Drug interaction of Cefotetan is with Alcohol, Anticoagulant ,  NA

  ►    Mechanism of Drug Drug Interaction :  A disulfiram-like interaction with alcohol may occur.Cefotetan may enhance the hypoprothrombinaemic response to anticoagulants. ,
Ref :-   Book : Martindale    Page : 236,246   Edition : 38,


►  Contraindication : renal impairment, hypersensitive to other cephalosporins, penicillin-sensitive patient,
Ref :-   Book : Martindale    Page : 246,235   Edition : 38,
  ►  Mechanism of Action :   Cefotetan inhibits the bacterial growth by interfearing with the transpeptidation reaction of bacterial cell wall synthesis. Cefotetan is a structural analog of the natural D-Ala-D-Ala substrate, covalently bind to the active site of PBPs. This inhibits the transpeptidation reaction, halting peptidoglycan synthesis, and the cell dies. ,
Ref :-   Book : Basic & Clinical pharmacology    Page : 792   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Red algae with Another pathway,

  ►  Pathway with its reference as follows :-
  • Antibiotic effect --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal, Biliary,
    Ref :-   Book : Martindale    Page : 246   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   3 hours,    Max value :-   4.6 hours,
    Ref :-   Book : Martindale    Page : 246   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   peak plasma concentrat ions of about 70 micrograms/mL at 1 hour and 90 micrograms/mL at 3 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 246   Edition : 38,