Cefoxitin is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 247   Edition : 38,

  ►   Brandname : Mefoxin; Daliding

  ►  Strength : Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 807   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, IM,
Reference :-   Book : Martindale    Page : 246   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Uncomplicated infection IM 1 gm Injection t.i.d/q.i.d
2 Uncomplicated urinary-track infection IM 1 gm Injection b.d.
3 Surgical infection prophylaxis IM or IV 2 gm Injection 30 tO 60 min before the procedure.

Ref :-  Book : Martindale    Page : 246   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Susceptible bacterial infections less than 1 Day less than 28 Day IM 20 40 mg/kg Injection b.d.
2 Severe infections IM 20 40 mg/kg Injection t.i.d/q.i.d

Ref :- Book : Martindale    Page : 246   Edition : 38,
►  Side Effect : gastrointestinal disturbance, convulsion, CNS toxicity, abnormal liver fuction tests, hypersensitivity reactions, fever, Platelet dysfunction,
Ref :-   Book : Martindale    Page : 235, 246   Edition : 38, Martindale    Page : 246,235   Edition : 38,

►  Drug Interaction : Drug interaction of Cefoxitin is with Probenecid ,
Ref :-   Book : Martindale    Page : 247   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Probenecid reduces the renal clearance of cefoxitin.,
Ref :-   Book : Martindale    Page : 247   Edition : 38,


►  Contraindication : penicillin-sensitive patient, renal impairment, hypersensitive to other cephalosporins,
Ref :-   Book : Martindale    Page : 246,235   Edition : 38,
  ►  Mechanism of Action :   It inhibits the bacterial growth by interfearing with the transpeptidation reaction of bacterial cell wall synthesis. Cefoxitin is a structural analog of the natural D-Ala-D-Ala substrate, covalently bind to the active site of PBPs. This inhibits the transpeptidation reaction, halting peptidoglycan synthesis, and the cell dies,
Ref :-   Book : Basic & Clinical pharmacology    Page : 792   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Red algae with Another pathway, Eucalyptus oil with Another pathway,

  ►  Pathway with its reference as follows :-
  • Antibiotics property --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • another pathway --- (Antibacterial activity of the essential oils from the leaves of Eucalyptus globulus against Escherichia coli and Staphylococcus aureus. (2016). )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html, http://www.ncbi.nlm.nih.gov/pubmed/23570005,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 250   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   45,    Max value :-   60 min,
    Ref :-   Book : Martindale    Page : 247   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   20 ,    Max value :-   30 min,
    Ref :-   Book : Martindale    Page : 247   Edition : 38,