Cefoxitin is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 247   Edition : 38  

  ►   Brandname : Mefoxin; Daliding
  ►  Strength : Injection with

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 807   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, IM
Reference :-   Book : Martindale    Page : 246   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Uncomplicated infection IM 1 gm Injection t.i.d/q.i.d
2 Uncomplicated urinary-track infection IM 1 gm Injection b.d.
3 Surgical infection prophylaxis IM or IV 2 gm Injection 30 tO 60 min before the procedure.

Ref :-  Book : Martindale    Page : 246   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Susceptible bacterial infections less than 1 Day less than 28 Day IM 20 40 mg/kg Injection b.d.
2 Severe infections IM 20 40 mg/kg Injection t.i.d/q.i.d

Ref :- Book : Martindale    Page : 246   Edition : 38  
►  Side Effect : Gastrointestinal disturbance, Convulsion, CNS toxicity, Abnormal liver fuction tests, Hypersensitivity reactions, Fever, Platelet dysfunction
Ref :-   Book : Martindale    Page : 235, 246   Edition : 38.   Martindale    Page : 246,235   Edition : 38.  

►  Drug Interaction : Drug interaction of Cefoxitin is with Probenecid
Ref :-   Book : Martindale    Page : 247   Edition : 38.  


  ►    Mechanism of Drug Drug Interaction :  Probenecid reduces the renal clearance of cefoxitin.
Ref :-   Book : Martindale    Page : 247   Edition : 38.  


►  Contraindication : Penicillin-sensitive patient, Renal impairment, Hypersensitive to other cephalosporins
Ref :-   Book : Martindale    Page : 246,235   Edition : 38.  
  ►  Mechanism of Action :   It inhibits the bacterial growth by interfearing with the transpeptidation reaction of bacterial cell wall synthesis. Cefoxitin is a structural analog of the natural D-Ala-D-Ala substrate, covalently bind to the active site of PBPs. This inhibits the transpeptidation reaction, halting peptidoglycan synthesis, and the cell dies
Ref :-   Book : Basic & Clinical pharmacology    Page : 792   Edition : 12.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Red algae with Another pathway.   Eucalyptus oil with Another pathwayAnother pathway.   Eucalyptus oil with Another pathwayAnother pathway.  

  ►  Pathway with its reference as follows :-
  • another pathway --- (Antibacterial activity of the essential oils from the leaves of Eucalyptus globulus against Escherichia coli and Staphylococcus aureus. (2016). )
  • Antibiotic effect --- (Duck, J. (2002). Hand Book Of Medicinal Herbs (2nd ed.). America: CRC. )
  • another pathway --- (Antibacterial activity of the essential oils from the leaves of Eucalyptus globulus against Escherichia coli and Staphylococcus aureus. (2016). )
  • Antibiotic effect --- (Duck, J. (2002). Hand Book Of Medicinal Herbs (2nd ed.). America: CRC. )
  • Antibiotics property --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL --
  • http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html .
  • http://www.ncbi.nlm.nih.gov/pubmed/23570005 .
  • https://books.google.co.in/books?id=B_XLBQAAQBAJ&pg=PP6&dq=Handbook+of+Medicinal+Herbs .
  • +Second+Edition&hl=en&sa=X&redir_esc=y#v=onepage&q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition&f=false .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal
    Ref :-   Book : Martindale    Page : 250   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   45,    Max value :-   60 min.  
    Ref :-   Book : Martindale    Page : 247   Edition : 38.  

    ►    Peak Plasma Concentration :   Min value :-   20 ,    Max value :-   30 min.  
    Ref :-   Book : Martindale    Page : 247   Edition : 38.