Ceftizoxime Sodium is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 253   Edition : 38  

  ►   Brandname : Cefizox, Eldcef
  ►  Strength : Injection with

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 807   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, IM
Reference :-   Book : Martindale    Page : 253   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 SEVERE INFECTION IV 2 4 gm Injection t.i.d.
2 Uncomplicated urinary-track infection IV 500 mg Injection b.d.
3 Uncomplicated gonorrhoea IM 1 gm Injection A single dose.
4 Life-threatening infections IV Up to 2 gm Injection Every 4 hr.

Ref :-  Book : Martindale    Page : 253   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Mild to moderate infections 1 Month more than 1 Month IM or IV 150 mg/kg Injection
2 Severe infections 1 Month more than 1 Month i.v/i.m 150 200 mg/kg Injection
3 Anorectal gonococcal infection IM 500 mg Injection

Ref :- Book : Martindale    Page : 253   Edition : 38   Nelson's textbook of Pediatrics    Page : 938   Edition : 19  
►  Side Effect : Eosinophilia, Skin rashes, Anaphylaxis, Serum-sickness, Hypersensitivity reactions, Fever, Urticaria
Ref :-   Book : Martindale    Page : 235, 244, 253   Edition : 38.   Martindale    Page : 253,244,235   Edition : 38.  

►  Drug Interaction : Drug interaction of Ceftizoxime Sodium is with Probenecid
Ref :-   Book : Martindale    Page : 253   Edition : 38.  


  ►    Mechanism of Drug Drug Interaction :  Probenecid reduces the renal clearance of ceftizoxime.
Ref :-   Book : Martindale    Page : 253   Edition : 38.  


►  Contraindication : Hypersensitive to other cephalosporins, Penicillin-sensitive patient, Renal impairment
Ref :-   Book : Martindale    Page : 253,244,235   Edition : 38.  
  ►  Mechanism of Action :   Ceftizoxime Sodium inhibits the bacterial growth by interfearing with the transpeptidation reaction of bacterial cell wall synthesis. Ceftizoxime Sodium is a structural analog of the natural D-Ala-D-Ala substrate, covalently bind to the active site of PBPs. This inhibits the transpeptidation reaction, halting peptidoglycan synthesis, and the cell dies.
Ref :-   Book : Basic & Clinical pharmacology    Page : 792   Edition : 12.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Red algae with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Antibiotic effect --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL --
  • http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal
    Ref :-   Book : Martindale    Page : 253   Edition : 38.  

    ►    Plasma Half-life :   Min value :-   1.7 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 253   Edition : 38.  

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 253   Edition : 38.