Ceftizoxime Sodium is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 253   Edition : 38,

  ►   Brandname : Cefizox,Eldcef

  ►  Strength : Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 807   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, IM,
Reference :-   Book : Martindale    Page : 253   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 SEVERE INFECTION IV 2 4 gm Injection t.i.d.
2 Uncomplicated urinary-track infection IV 500 mg Injection b.d.
3 Uncomplicated gonorrhoea IM 1 gm Injection A single dose.
4 Life-threatening infections IV Up to 2 gm Injection Every 4 hr.

Ref :-  Book : Martindale    Page : 253   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Mild to moderate infections 1 Month more than 1 Month IM or IV 150 mg/kg Injection
2 Severe infections 1 Month more than 1 Month i.v/i.m 150 200 mg/kg Injection
3 Anorectal gonococcal infection IM 500 mg Injection

Ref :- Book : Martindale    Page : 253   Edition : 38, Nelson's textbook of Pediatrics    Page : 938   Edition : 19,
►  Side Effect : eosinophilia, Skin rashes, anaphylaxis, serum-sickness, hypersensitivity reactions, fever, Urticaria,
Ref :-   Book : Martindale    Page : 235, 244, 253   Edition : 38, Martindale    Page : 253,244,235   Edition : 38,

►  Drug Interaction : Drug interaction of Ceftizoxime Sodium is with Probenecid ,
Ref :-   Book : Martindale    Page : 253   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Probenecid reduces the renal clearance of ceftizoxime.,
Ref :-   Book : Martindale    Page : 253   Edition : 38,


►  Contraindication : hypersensitive to other cephalosporins, penicillin-sensitive patient, renal impairment,
Ref :-   Book : Martindale    Page : 253,244,235   Edition : 38,
  ►  Mechanism of Action :   Ceftizoxime Sodium inhibits the bacterial growth by interfearing with the transpeptidation reaction of bacterial cell wall synthesis. Ceftizoxime Sodium is a structural analog of the natural D-Ala-D-Ala substrate, covalently bind to the active site of PBPs. This inhibits the transpeptidation reaction, halting peptidoglycan synthesis, and the cell dies. ,
Ref :-   Book : Basic & Clinical pharmacology    Page : 792   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Red algae with Another pathway,

  ►  Pathway with its reference as follows :-
  • Antibiotic effect --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 253   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   1.7 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 253   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 253   Edition : 38,