Ceftriaxone is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 255   Edition : 38,    Page :   Edition : ,

  ►   Brandname : Cefocef,Ciplacef,Rocephin,Rocephin; Ansailong; Cefotrix; Acticef; Afzone,Monocef

  ►  Strength : Injection with 0.25  gm, Injection with 0.50  gm, Injection with 1  gm, Injection with 2  gm, Injection with 10  gm,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 807   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IM, IV,
Reference :-   Book : Martindale    Page : 258   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Uncomplicated gonorrhoea IM 250 mg Injection Given as a Single dose.
2 Meningococcal meningitis IM 250 mg Injection Given as a Single dose.
3 Surgical infection prophylaxis IM 1 gm Injection Given as a Single dose.
4 Infections IV 1 2 gm Injection Given as a Single dose or in two divided dose.
5 Severe infections IV Up to 4 gm Injection Daily.

Ref :-  Book : Martindale    Page : 254   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Susceptible bacterial infections IM or IV 20 50 mg/kg Injection o.d.
2 Susceptible bacterial infections 1 Month Above 1 Month less than 50 kg IM or IV 50 mg/kg Injection o.d.
3 Susceptible bacterial infections more than 50 kg IM or IV 1 gm Injection
4 Severe infections 1 Month Above 1 Month less than 50 kg IM or IV up to 80 mg/kg Injection
5 Severe infections more than 50 kg IM or IV 2 4 gm Injection

Ref :- Book : Martindale    Page : 254   Edition : 38,
Precaution :- If a Patient is using 'Ceftriaxone' drug in  auto immune hemolytic anemia  disease, then Please Do not use .

►  Side Effect : diarrhoea, hypersensitivity reactions, Skin rashes, Urticaria, eosinophilia, fever, serum-sickness, anaphylaxis, neutropenia,
Ref :-   Book : Martindale    Page : 254   Edition : 38, Martindale    Page : 254,235   Edition : 38,

►  Drug Interaction : Drug interaction of Ceftriaxone is with Alcohol, Anticoagulant ,  Probenecid ,
Ref :-   Book : Martindale    Page : 254   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Ceftriaxone has an N-methylthiotriazine side-chain and may have the potential to increase the effects of anticoagulants and to cause a disulfiram-like reaction with alcohol. Isolated cases of death in term or premature neonates have been associated with precipitation of calcium ceftriaxone in lungs and kidneys.,
Ref :-   Book : Martindale    Page : 254   Edition : 38,


►  Contraindication : Jaundiced neonates, Prematured neonate,
Ref :-   Book : Martindale    Page : 254   Edition : 38,
  ►  Mechanism of Action :   Ceftriaxone inhibits the bacterial growth by interfearing with the transpeptidation reaction of bacterial cell wall synthesis. Ceftriaxone is a structural analog of the natural D-Ala-D-Ala substrate, covalently bind to the active site of PBPs. This inhibits the transpeptidation reaction, halting peptidoglycan synthesis, and the cell dies,
Ref :-   Book : Basic & Clinical pharmacology    Page : 792   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Red algae with Another pathway, Almond oil with Another pathway,

  ►  Pathway with its reference as follows :-
  • antibiotics effects --- ( Kokate, C. (2013). Pharmacognosy. Pune: Nirali Prakashan. )
  • Antibiotic effect --- (Duck, J. (2002). Hand Book Of Medicinal Herbs (2nd ed.). America: CRC. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html, https://books.google.co.in/books?id=B_XLBQAAQBAJ&pg=PP6&dq=Handbook+of+Medicinal+Herbs, +Second+Edition&hl=en&sa=X&redir_esc=y#v=onepage&q=Handbook%20of%20Medicinal%20Herbs%2C%20Second%20Edition&f=false,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- IRON with Dietary Substance is Drug Inhibitor,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Biliary, Fecal, Renal,
    Ref :-   Book : Martindale    Page : 258   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   6 hours,    Max value :-   9 hours,
    Ref :-   Book : Martindale    Page : 258   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 258   Edition : 38,