Cefuroxime is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 256   Edition : 38  

  ►   Brandname : Actum, Adexim, Zinacef, AoShu; Axetine; Cefuhexal; Aprokam
  ►  Strength : Tablet with 125 mg.  Tablet with 250 mg.  Tablet with 500 mg.  Suspension with 125/5 mg/ml.  Suspension with 250/5 mg/ml.  Injection with 0.75 gm.  Injection with 1.5 gm.  Injection with 7.5 gm. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 807   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IM, IV, Oral, Intracameral injection
Reference :-   Book : Martindale    Page : 255   Edition : 38   Martindale    Page : 256   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Uncomplicated urinary-tract infections Oral 125 mg b.d.
2 Respiratory- tract infections Oral 250 500 mg b.d.
3 Lyme disease Oral 500 mg b.d. for 20 days.
4 Meningitis IV 3 gm Injection t.i.d. Due to sensitive strains of bacteria.
5 Pneumonia parenteral 1.5 gm Injection b.d.
6 Chronic BRONCHITIS parenteral 750 mg Injection b.d.
7 Surgical infection prophylaxis IV 1.5 gm Injection Before the procedure.
8 Total joint replacement parenteral 1.5 gm Injection cefuroxime powder may be mixed with the methylmethacrylate cement.
9 Prophylaxis of POSTOPERATIVE ENDOPHTHALMITIS Intracameral injection 1 mg Injection slowly injected into the anterior chamber of eye at the end of cataract surgery.
10 Gonorrhoea IM 1.5 gm Injection A single dose ,divided between 2 injection.
11 Uncomplicated urinary-tract infections Oral 250 mg b.d.
12 Severe infections IV 750 mg Injection t.i.d.
13 More SEVERE INFECTIONS IV 1.5 gm Injection t.i.d/q.i.d

Ref :-  Book : Martindale    Page : 255   Edition : 38   Martindale    Page : 255,256   Edition : 38   Martindale    Page : 256   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Susceptible bacterial infections 3 Month 2 Year Oral 10 mg/kg Tablet b.d.
2 Susceptible bacterial infections more than 2 Year Oral 15 mg/kg Tablet b.d.
3 Surgical infection prophylaxis 3 Month 2 Year Oral 10 mg/kg Tablet b.d.
4 Surgical infection prophylaxis more than 2 Year Oral 15 mg/kg Tablet b.d.
5 SEVERE INFECTION 1 Month IV 20 mg/kg Injection t.i.d.
6 Susceptible bacterial infections Under 7 Day IM or IV 25 mg/kg Injection b.d.
7 Susceptible bacterial infections 7 Day 21 Day IM or IV 25 mg/kg Injection t.i.d.
8 Susceptible bacterial infections 21 Day 28 Day IM or IV 25 mg/kg Injection q.i.d.
9 SEVERE INFECTION IV 50 mg/kg Injection

Ref :- Book : Martindale    Page : 256   Edition : 38  
►  Side Effect : Gastrointestinal disturbance, Diarrhea, Nausea, Vomiting, Mild to moderate hearing loss, Hypersensitivity reactions, Skin rashes, Urticaria, Eosinophilia, Fever, Serum-sickness, Anaphylaxis
Ref :-   Book : Martindale    Page : 256   Edition : 38.   Martindale    Page : 256   Edition : 38.   Martindale    Page : 256,235   Edition : 38.  

►  Drug Interaction : Drug interaction of Cefuroxime is with Probenecid
Ref :-   Book : Martindale    Page : 256   Edition : 38.  


  ►    Mechanism of Drug Drug Interaction :  Probenecid reduces the renal clearance of cefuroxime.
Ref :-   Book : Martindale    Page : 256   Edition : 38.  


►  Contraindication : Renal impairment, Penicillin-sensitive patient, Hypersensitive to other cephalosporins
Ref :-   Book : Martindale    Page : 256,235   Edition : 38.  
  ►  Mechanism of Action :   It inhibits the bacterial growth by interfearing with the transpeptidation reaction of bacterial cell wall synthesis. Cefuroxime. is a structural analog of the natural D-Ala-D-Ala substrate, covalently bind to the active site of PBPs. This inhibits the transpeptidation reaction, halting peptidoglycan synthesis, and the cell dies.
Ref :-   Book : Basic & Clinical pharmacology    Page : 792   Edition : 12.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Eucalyptus oil with Another pathway.  

  ►  Pathway with its reference as follows :-
  • 1-8 cineole have Antibiotic property. --- (Bachir, R. & Benali, M. (2012). Antibacterial activity of the essential oils from the leaves of Eucalyptus globulus against Escherichia coli and Staphylococcus aureus. Asian Pacific Journal Of Tropical Biomedicine, 2(9), 739-742. )

  •   ►  URL --
  • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609378/ .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal, Biliary
    Ref :-   Book : Martindale    Page : 256   Edition : 38.  

    ►    Plasma Half-life :   Min value :-   70 min,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 256   Edition : 38.  

    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   3 hours.  
    Ref :-   Book : Martindale    Page : 256   Edition : 38.