Cefuroxime is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 256   Edition : 38,

  ►   Brandname : Actum,Adexim,Zinacef,AoShu; Axetine; Cefuhexal; Aprokam

  ►  Strength : Tablet with 125  mg, Tablet with 250  mg, Tablet with 500  mg, Suspension with 125/5  mg/ml, Suspension with 250/5  mg/ml, Injection with 0.75  gm, Injection with 1.5  gm, Injection with 7.5  gm,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 807   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IM, IV, Oral, Intracameral injection,
Reference :-   Book : Martindale    Page : 255   Edition : 38, Martindale    Page : 256   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Uncomplicated urinary-tract infections Oral 125 mg b.d.
2 Respiratory- tract infections Oral 250 500 mg b.d.
3 Lyme disease Oral 500 mg b.d. for 20 days.
4 Meningitis IV 3 gm Injection t.i.d. Due to sensitive strains of bacteria.
5 Pneumonia parenteral 1.5 gm Injection b.d.
6 Chronic BRONCHITIS parenteral 750 mg Injection b.d.
7 Surgical infection prophylaxis IV 1.5 gm Injection Before the procedure.
8 Total joint replacement parenteral 1.5 gm Injection cefuroxime powder may be mixed with the methylmethacrylate cement.
9 Prophylaxis of POSTOPERATIVE ENDOPHTHALMITIS Intracameral injection 1 mg Injection slowly injected into the anterior chamber of eye at the end of cataract surgery.
10 Gonorrhoea IM 1.5 gm Injection A single dose ,divided between 2 injection.
11 Uncomplicated urinary-tract infections Oral 250 mg b.d.
12 Severe infections IV 750 mg Injection t.i.d.
13 More SEVERE INFECTIONS IV 1.5 gm Injection t.i.d/q.i.d

Ref :-  Book : Martindale    Page : 255   Edition : 38, Martindale    Page : 255,256   Edition : 38, Martindale    Page : 256   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Susceptible bacterial infections 3 Month 2 Year Oral 10 mg/kg Tablet b.d.
2 Susceptible bacterial infections more than 2 Year Oral 15 mg/kg Tablet b.d.
3 Surgical infection prophylaxis 3 Month 2 Year Oral 10 mg/kg Tablet b.d.
4 Surgical infection prophylaxis more than 2 Year Oral 15 mg/kg Tablet b.d.
5 SEVERE INFECTION 1 Month IV 20 mg/kg Injection t.i.d.
6 Susceptible bacterial infections Under 7 Day IM or IV 25 mg/kg Injection b.d.
7 Susceptible bacterial infections 7 Day 21 Day IM or IV 25 mg/kg Injection t.i.d.
8 Susceptible bacterial infections 21 Day 28 Day IM or IV 25 mg/kg Injection q.i.d.
9 SEVERE INFECTION IV 50 mg/kg Injection

Ref :- Book : Martindale    Page : 256   Edition : 38,
►  Side Effect : gastrointestinal disturbance, diarrhea, nausea, vomiting, Mild to moderate hearing loss, hypersensitivity reactions, Skin rashes, Urticaria, eosinophilia, fever, serum-sickness, anaphylaxis,
Ref :-   Book : Martindale    Page : 256   Edition : 38, Martindale    Page : 256   Edition : 38, Martindale    Page : 256,235   Edition : 38,

►  Drug Interaction : Drug interaction of Cefuroxime is with Probenecid ,
Ref :-   Book : Martindale    Page : 256   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Probenecid reduces the renal clearance of cefuroxime. ,
Ref :-   Book : Martindale    Page : 256   Edition : 38,


►  Contraindication : renal impairment, penicillin-sensitive patient, hypersensitive to other cephalosporins,
Ref :-   Book : Martindale    Page : 256,235   Edition : 38,
  ►  Mechanism of Action :   It inhibits the bacterial growth by interfearing with the transpeptidation reaction of bacterial cell wall synthesis. Cefuroxime. is a structural analog of the natural D-Ala-D-Ala substrate, covalently bind to the active site of PBPs. This inhibits the transpeptidation reaction, halting peptidoglycan synthesis, and the cell dies. ,
Ref :-   Book : Basic & Clinical pharmacology    Page : 792   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Eucalyptus oil with Another pathway,

  ►  Pathway with its reference as follows :-
  • 1-8 cineole have Antibiotic property. --- (Bachir, R. & Benali, M. (2012). Antibacterial activity of the essential oils from the leaves of Eucalyptus globulus against Escherichia coli and Staphylococcus aureus. Asian Pacific Journal Of Tropical Biomedicine, 2(9), 739-742. )

  •   ►  URL -- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609378/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal, Biliary,
    Ref :-   Book : Martindale    Page : 256   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   70 min,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 256   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   3 hours,
    Ref :-   Book : Martindale    Page : 256   Edition : 38,