Celecoxib is a Medicine belongs to NONSTEROIDAL ANTI-INFLAMMATORY DRUGS group whose information about Brand can be referenced from   Book : Martindale    Page : 39   Edition : 38,

  ►   Brandname : Celebrex; Onsenal; Celact; Celcib; Celcox; Celecap; Celedol

  ►  Strength : Capsule with 50  mg, Capsule with 100  mg, Capsule with 200  mg, Capsule with 400  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 655   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 36   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Rheumatoid arthiritis Oral 100 200 mg Capsule b.d.
2 Dysmenorrhea Oral 400 mg Capsule
3 Osteoarthritis Oral 200 mg Capsule Given as a single dose, or in 2 divided doses
4 Ankylosing spondylitis Oral 200 mg Capsule Given as a single dose, or in 2 divided doses.
5 Pain Oral 400 mg Capsules

Ref :-  Book : Martindale    Page : 36   Edition : 38, Martindale    Page : 37   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Juvenile idiopathic arthritis 2 Year more than 2 Year 10 kg to 25 kg Oral 50 mg Capsule b.d.
2 Juvenile idiopathic arthritis 2 Year more than 2 Year over 25 kg Oral 100 mg Capsule b.d.

Ref :- Book : Martindale    Page : 37   Edition : 38,
►  Side Effect : gastrointestinal disturbance, nausea, diarrhea, headache, vertigo, Dizziness, Nervousness, tinnitus, Depression, drowsiness, insomnia, amnesia, thrombocytopenia, neutropenia, agranulocytosis, Stevens-Johnson syndrome, toxic epidermal necrolysis, anaphylaxis, angioedema, Serious skin reaction, hypersensitivity reactions, dermatitis,
Ref :-   Book : Martindale    Page : 37,104   Edition : 38, Martindale    Page : 37   Edition : 38,

►  Drug Interaction : Drug interaction of Celecoxib is with ,  Fluconazole ,
Ref :-   Book : Martindale    Page : 38   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Drugs that inhibit or induce or are metabolised by this isoenzyme may result in changes in plasma concentration of celecoxib; fluconazole has increased plasma concentrations of celecoxib.,
Ref :-   Book : Martindale    Page : 38   Edition : 38,


►  Contraindication : hypersensitive to sulfonamides, Hypersensitivity to celecoxib, asthma, urticaria, Allergic type reactions after taking NSAIDS, anaphylactic reaction, Pain assosiated with Coronary Artery bypass graft Surgery, Moderate to severe heart failure, inflammatory bowel disease, renal impairment, Severe hepatic impairment, Dehydrated patients, Treatment may need to be stopped if signs or symptoms of organ toxicity develop, ischaemic heart disease, peripheral arterial disease, Cerebrovascular disease,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 762   Edition : 3, Martindale    Page : 37   Edition : 38,
  ►  Mechanism of Action :   Selective inhibition of COX-2,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 762   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Aloe vera with same pathway,

  ►  Pathway with its reference as follows :-
  • anti-inflammatory effect COX-2 inhibitor . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- SODIUM with Increase in Nutrient Level, POLONIUM with Increase in Nutrient Level,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- WILLOW BARK with Together increases the likelihood of developing stomach and intestinal ulcers ., CANNABIS with Cannabis antagonist the effect of NSAIDs,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf, https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,

    ►   Route of Elimination :   Fecal, Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 38   Edition : 38,


    ►    Plasma Half-life :   Min value :-   11 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 37   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   3 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 38   Edition : 38,