Chlorambucil is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 765   Edition : 38,

  ►   Brandname : Leukeran

  ►  Strength : Tablet with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 765   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 765   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Chronic lymphocytic leukaemia Oral 100 200 micrograms/kg Tablet Daily For 3 to 8 weeks.
2 Lymphomas Oral 100 200 micrograms/kg Tablet Daily for 3 to 8 weeks.
3 Non Hodgkin’s lymphoma Oral 100 micrograms/kg Tablet Daily.
4 Waldenström’s macroglobulinaemia Oral 6 12 mg Tablet Daily, until leucopenia develops.
5 Hodgkin’s disease Oral 200 micrograms/kg Tablet Daily.

Ref :-  Book : Martindale    Page : 764   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
Precaution :- If a Patient is using 'Chlorambucil' drug in  Generalized, Tonic-Clonic Seizures  disease, then Please dont give .

►  Side Effect : gastrointestinal disturbance, azoospermia, amenorrhoea, pulmonary fibrosis, neutropenia, hepatotoxicity, Skin rashes, seizures, Interstitial pneumonia, pancytopenia, neurotoxicity, mutagenic, teratogenic, carcinogenic, ataxia, bone marrow depression,
Ref :-   Book : Martindale    Page : 764   Edition : 38,

►  Drug Interaction : Drug interaction of Chlorambucil is with vaccine , Live Vaccines, ,  NA

  ►    Mechanism of Drug Drug Interaction :  Antineoplastics that have an immunosuppressant effect may reduce the response to vaccines, and there is a possibility of generalised infection with live vaccines. Use with live vaccines should generally be avoided. Many antineoplastics are inhibitors of certain isoenzymes of cytochrome P450 and some antineoplastics are also metabolised by these enzymes.,
Ref :-   Book : Martindale    Page : 764,733   Edition : 38,


►  Contraindication : renal impairment, hepatic dysfunction, nephrotic syndrome, It Should be avoided, or given with great care and at reduced doses, for at least 4 weeks after treatment with radiotherapy or other antineoplastics.,
Ref :-   Book : Martindale    Page : 764   Edition : 38,
  ►  Mechanism of Action :   Covalently bind DNA, often cross-link to DNA or associated proteins.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 696   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Vinca with Another pathway,

  ►  Pathway with its reference as follows :-
  • Vincristine and vinblastine arrests multiplication of cancerous cells --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy, +C.+K.+Kokate, +A.P.+Purohit, +S.B.+Gokhale,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- VITAMIN B6 with Increases urinary vit B6 excretion.,

      ►  Reference :-
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 765   Edition : 38,


    ►    Plasma Half-life :   Min value :-   1.5 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 765   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA