Chloramphenicol is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 259   Edition : 38,

  ►   Brandname : Chloraxin,Biophenicol,Clorogen,Chloromycetin; Brochlor; Kemicetine; Paraxin;

  ►  Strength : Injection with 100  mg, Capsule with   , Eye Drop with   , Ear Drop with 5  %, Ointment with 1  %, Suspension with   , Cream with   , Solution with 0.5  %,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 819   Edition : 12, Martindale    Page : 260   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, Oral, Topical,
Reference :-   Book : Martindale    Page : 260   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Meningitis Up to 100 mg/kg Daily.
2 Severe infections Up to 100 mg/kg Daily.
3 Meningitis 50 mg/kg Daily in divided doses every 6 and 8 hours.
4 Severe infections 50 mg/kg Daily in divided doses every 6 and 8 hours.
5 Eye infections Topical Solution t.i.d/q.i.d 0.5 % At Day.
6 Otitis externa Topical Ear Drop t.i.d/q.i.d 5 % and 10 %, 2 or 3 drops.
7 Eye infections Topical Ointment 1 % Once daily at night.

Ref :-  Book : Martindale    Page : 257   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Cystic fibrosis IV 50 100 mg/kg/day Injection q.i.d.
2 Plague IV 25 mg/kg Injection q.i.d.
3 Antibiotic 0Week 4Week Less than 1200 gm Oral / i.v 25 mg/kg o.d.
4 Antibiotic less than 1 Day 7 Day 1200-2000 gm Oral / i.v 25 mg/kg o.d.
5 Antibiotic more than 7 Day 1200-2000 gm Oral / i.v 25 mg/kg o.d.
6 Antibiotic less than 1 Day 7 Day more than 2000 gm Oral / i.v 25 mg/kg o.d.
7 Antibiotic more than 7 Day more than 2000 gm Oral / i.v 25 mg/kg b.d.
8 Meningitis IV 50 100 mg/kg/day Injection q.i.d.

Ref :- Book : Nelson's textbook of Pediatrics    Page : 1492   Edition : 19, Nelson's textbook of Pediatrics    Page : 2454   Edition : 19, Nelson's textbook of Pediatrics    Page : 645   Edition : 19, Nelson's textbook of Pediatrics    Page : 933   Edition : 19,
Precaution :- If a Patient is using 'Chloramphenicol' drug in  Typhoid  disease, then Please Contraindicated in pregnancy. .

►  Side Effect : bone marrow depression, anaemia, leucopenia, thrombocythaemia, Gray baby syndrome, vomiting, hypothermia, Progressive pallid cyanosis, Confusion, Reticulocytopenia, hypersenstivity, Rashes, fever, angioedema, rectal irritation, glossitis, delirium, Depression, headache, ototoxicity,
Ref :-   Book : Martindale    Page : 261   Edition : 37,

►  Drug Interaction : Drug interaction of Chloramphenicol is with Dermatological drug , , ,  Phenytoin , Tolbutamide , Chlorpropamide , Warfarin , Rifampicin , Phenobarbital , Vitamin-b, Iron , Conivaptan ,
Ref :-   Book : Martindale    Page : 258   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Chloramphenicol is inactivated in the liver and may, therefore, interact with drugs that are metabolised by hepatic microsomal enzymes. Chloramphenicol enhances the effects of coumarin anticoagulants, such as dicoumarol and warfarin, and chlorpropamide, tolbutamide, phenytoin. Chloramphenicol may decrease the effects of iron and vitamin B12 in anaemic patients and has occasionally impaired the action of oral contraceptives. Conversely, the metabolism of chloramphenicol may be increased by inducers of hepatic enzymes such as phenobarbital or rifampicin.,
Ref :-   Book : Martindale    Page : 258   Edition : 38,


►  Contraindication : Hypersensitivity, bone marrow depression, blood dyscrasias, active immunisation,
Ref :-   Book : Martindale    Page : 258   Edition : 38,
  ►  Mechanism of Action :   Chloramphenicol acts primarily by binding reversibly to the 50S ribosomal subunit (near the binding site for the macrolide antibiotics and clindamycin, which chloramphenicol inhibits competitively).,
Ref :-   Book : Goodman    Page : 1527   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- with Another pathway, Coconut oil with Another pathway,

  ►  Pathway with its reference as follows :-
  • Berberine have Anti-infective effect. --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )
  • Anti bacterial property --- (Ogbolu, D., Oni, A., Daini, O., & Oloko, A. (2007). In Vitro Antimicrobial Properties of Coconut Oil on Candida Species in Ibadan, Nigeria. Journal Of Medicinal Food, 10(2), 384-387. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf, http://www.ncbi.nlm.nih.gov/pubmed/17651080,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- VITAMIN B12 with Reduces vit B 12 absorption., FOLATE with Increases folate requirement.,

      ►  Reference :-
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,

    ►   Route of Elimination :   Biliary, Hepatic (Metabolism), Renal, Faecal,
    Ref :-   Book : Martindale    Page : 259   Edition : 38,


    ►    Plasma Half-life :   Min value :-   1.5 hours,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 259   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA