Chlordiazepoxide is a Medicine belongs to Sedative-hypnotics/ benzodiazepines group whose information about Brand can be referenced from   Book : Martindale    Page : 1045   Edition : 38,    Page :   Edition : ,

  ►   Brandname : Librium,Tropium,Equilibrium; Anxizide; Cebrum,Normaxin,Normaxin RT

  ►  Strength : Capsule with 5  mg, Capsule with 10  mg, Capsule with 25  mg, Tablet with   , Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 387   Edition : 12, Martindale    Page : 1045   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV, IM,
Reference :-   Book : Martindale    Page : 1044   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Anxiety disorders Oral Up to 30 mg dose "daily in divided doses"
2 Severe conditions Oral Up to 100 mg dose "daily"
3 Muscle spasm Oral 10 30 mg dose "daily in divided doses"
4 Alcohol withdrawal Oral 25 100 mg dose"maximum 300 mg daily."
5 Insomnia associated with anxiety Oral 10 30 mg Before bed time.

Ref :-  Book : Martindale    Page : 1044   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Anxiety disorders 6 Year more than 6 Year Oral 5 mg
2 Pre- operative apprehension 6 Year More than 6 Year Oral 5 mg

Ref :- Book : Martindale    Page : 1044   Edition : 38,
►  Side Effect : drowsiness, Sedation, muscle weakness, ataxia, vertigo, headache, Confusion, Depression, slurred speech, dysesthesias, changes in libido, tremor, visual disturbances, urinary retention, incontinence, gastrointestinal disturbance, changes in salivation, amnesia, hostility, aggression, disinhibition, respiratory depression, hypotension, Pain, thrombophlebitis, jaundice, blood disorder, fatalities, hypersensitivity reactions,
Ref :-   Book : Martindale    Page : 1044,1065   Edition : 38,

►  Drug Interaction : Drug interaction of Chlordiazepoxide is with Alcohol, CNS depressant, Sedative antihistamines, General anaesthetics , Antipsychotic , opioid analgesics, Antidepressant ,  NA

  ►    Mechanism of Drug Drug Interaction :  Enhanced sedation or respiratory and cardiovascular depression may occur if diazepam or other benzodiazepines are given with other drugs that have CNSdepressant properties; these include alcohol, antidepressants, sedative antihistamines, antipsychotics, general anaesthetics, other hypnotics or sedatives, and opioid analgesics.,
Ref :-   Book : Martindale    Page : 1044,1068   Edition : 38,


►  Contraindication : CNS depressant, coma, respiratory depression, acute pulmonary insufficiency, Myasthenia gravis, sleep apnea, Severe hepatic impairment,
Ref :-   Book : Martindale    Page : 1044,1066   Edition : 38,
  ►  Mechanism of Action :   Its actions are mediated by enhancement of the activity of gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain.,
Ref :-   Book : Martindale    Page : 1044,1063   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Calcium with Another pathway,

  ►  Pathway with its reference as follows :-
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  •   ►  URL -- ,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- with Puerarin reduce the effect of chlordiazepoxide ,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 1045   Edition : 38,


    ►    Plasma Half-life :   Min value :-   5 hours,    Max value :-   30 hours,
    Ref :-   Book : Martindale    Page : 1044   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   2 hours,
    Ref :-   Book : Martindale    Page : 1044   Edition : 38,