Chloroquine is a Medicine belongs to antimalarial group whose information about Brand can be referenced from   Book : Martindale    Page : 654   Edition : 38,

  ►   Brandname : Clokit,Emquin,Lariago,Maliago,Melubrin,Avloclor,Malarivon,Aralen; Resochin

  ►  Strength : Tablet with 250  mg, Tablet with 500  mg, Injection with 50  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 935   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV, IM, SC,
Reference :-   Book : Martindale    Page : 650   Edition : 38, Martindale    Page : 654   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Malaria Oral 25 mg/kg Tablet over 3 days
2 Malaria IV infusion 25 mg/kg Injection over 30 to 32 hours
3 Hepatic amoebiasis 600 mg daily for 2 days.
4 Lupus erythematosus 150 mg daily.
5 Light sensitive skin eruption 150 300 mg
6 Prophylaxis of malaria 300 mg Given once each week.
7 Rheumatoid arthiritis 150 mg Daily.

Ref :-  Book : Martindale    Page : 650   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Malaria 25 mg/kg
2 Prophylaxis of malaria Oral 5 mg/kg Tablet

Ref :- Book : Martindale    Page : 650   Edition : 38,
Precaution :- If a Patient is using 'Chloroquine' drug in  Malaria  disease, then Please be avoided in patients of Psoriasis .

Precaution :- If a Patient is using 'Chloroquine' drug in  Generalized, Tonic-Clonic Seizures  disease, then Please Not to be given .

Precaution :- If a Patient is using 'Chloroquine' drug in  MYASTHENIA GRAVIS  disease, then Please Use with caution .

Precaution :- If a Patient is using 'Chloroquine' drug in  Acute Intermittent Porphyria  disease, then Please increase the porphyrin synthesis .

Precaution :- If a Patient is using 'Chloroquine' drug in  thallasemia  disease, then Please Avoid .

►  Side Effect : headache, skin eruptions, pruritus, gastrointestinal disturbance, nausea, diarrhea, hypotension, cardiac arrhythmia, Blurred Vision, respiratory arrest , keratopathy, blood disorder, coma, death, Dizziness, drowsiness, hypokalaemia, cardiovascular toxicity, pancytopenia, aplastic anaemia, thrombocytopenia, neutropenia,
Ref :-   Book : Martindale    Page : 652   Edition : 37,

►  Drug Interaction : Drug interaction of Chloroquine is with Halofantrine, Amiodarone , Moxifloxacin , Mefloquine , Sildenafil , kaolin,
Ref :-   Book : Martindale    Page : 654   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  There is an increased risk of inducing ventricular arrhythmias if chloroquine is used with halofantrine other arrhythmogenic drugs such as amiodarone and moxifloxacin. There is an increased risk of convulsions when chloroquine is given with mefloquine. The absorption of chloroquine can be reduced by kaolin and its metabolism may be inhibited by cimetidine.,
Ref :-   Book : Martindale    Page : 654   Edition : 37,


►  Contraindication : Myasthenia gravis, G6PD deficiency,
Ref :-   Book : Martindale    Page : 654   Edition : 37,
  ►  Mechanism of Action :   Decrease the metabolism and/or removal of toxic heme products, resulting in increased toxicity the plasmodia. ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 644   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Gun resin i.e. Boswellia serrata with Another pathway,

  ►  Pathway with its reference as follows :-
  • Resin acid have Anti-rheumatic effect --- (Chopra, A., Saluja, M., Tillu, G., Sarmukkaddam, S., Venugopalan, A., & Narsimulu, G. et al. (2013). Ayurvedic medicine offers a good alternative to glucosamine and celecoxib in the treatment of symptomatic knee osteoarthritis: a randomized, double-blind, controlled equivalence drug trial.Rheumatology, 52(8), 1408-1417. )

  •   ►  URL -- http://rheumatology.oxfordjournals.org/content/early/2013/01/30/rheumatology.kes414.long,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Clinical Pharmacology    Page : 272   Edition : 9,


    ►    Plasma Half-life :
      Min value :-   1 month,    Max value :-   2 mpnth,
    Ref :-   Book : Basic & Clinical pharmacology    Page : 916   Edition : 12,

    ►    Peak Plasma Concentration :   Min value :-   3 hours,    Max value :-   NA
    Ref :-   Book : Basic & Clinical pharmacology    Page : 916   Edition : 12,