Chlorpheniramine is a Medicine belongs to antihistamines group whose information about Brand can be referenced from   Book : Martindale    Page : 621   Edition : 38  

  ►   Brandname : Cofton, Allercalm, Allergy Relief, Allerief, Aller-Chlor, Cadistin; Allergy-Time
  ►  Strength : Chewable tablets with 2 mg.  Chewable tablets with 4 mg.  Syrup with 2/5 mg/ml.  sustained realease tablet with 8 mg.  sustained realease tablet with 12 mg.  sustained realease tablet with 16 mg.  Capsule with 8 mg.  Capsule with 12 mg.  Injection with

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 292   Edition : 12   Martindale    Page : 621   Edition : 38  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM, IV, SC, Topical
Reference :-   Book : Martindale    Page : 621   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 s.c, i.v, i.m 10 20 mg Injection Dose: over a period of 1 min.
2 Oral 4 mg Dose: 4 to 6 hours.

Ref :-  Book : Martindale    Page : 621   Edition : 38  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Allergic conditions 1 Year 2 Year Oral 1 mg b.d.
2 Allergic conditions 6 Year 12 Year Oral 2 mg
3 Allergic conditions 2 Year 6 Year Oral 1 mg
4 Anaphylactic shock 1 Month 1 Year s.c, i.v, i.m 250 micrograms/kg Injection
5 Anaphylactic shock 1 Year 5 Year s.c, i.v, i.m 2.5 5 mg
6 Anaphylactic shock 6 Year 12 Year s.c, i.v, i.m 5 10 mg Injection

Ref :- Book : Martindale    Page : 621   Edition : 38  
►  Side Effect : Exfoliative dermatitis, Transient hypotension, Stimulation of the CNS, CNS depression, Slight drowsiness to deep sleep, Lassitude, Dizziness, Incoordination, Paradoxical stimulation, Headache, Psychomotor impairment, Dry mouth, Thickened respiratory-tract secretions, Blurred Vision, Urinary difficulty or retention, Constipation, Gastric reflux, Nausea, Vomiting, Diarrhea, Weight gain, Anorexia, Rashes, Hypersensitivity reactions, Bronchospasm, Angioedema, Anaphylaxis, Convulsion, Sweating, Myalgia, Paresthesia, Extrapyramidal effects, Depression, Confusion, Tinnitus, Hypotension, Hair loss
Ref :-   Book : Martindale    Page : 621   Edition : 38.   Martindale    Page : 621,613   Edition : 38.  

►  Drug Interaction : Drug interaction of Chlorpheniramine is with Alcohol, Barbiturates , Hypnotic , opioid analgesics, Anxiolytic sedatives, Antipsychotic , Antimuscarinic, Tricyclic antidepressant , macrolide immunosuppressant , ,  Atropine
Ref :-   Book : Martindale    Page : 621,614   Edition : 38.  


  ►    Mechanism of Drug Drug Interaction :  Sedating antihistamines may enhance the sedative effects of CNS depressants including alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives and antipsychotics. Sedating antihistamines have an additive antimuscarinic action with other antimuscarinic drugs, such as atropine and some antidepressants (both tricyclics and MAOIs).
Ref :-   Book : Martindale    Page : 621,614   Edition : 38.  


►  Contraindication : alcohol administration, Operate machinery, Hepatic impairment, Cardiac disease, prolonged QT interval, Hypokalaemia, Pregnancy, Neonates
Ref :-   Book : Martindale    Page : 621,613   Edition : 38.  
  ►  Mechanism of Action :   Inverse agonists that bind preferentially to the inactive conformation of the H1 receptor and shift the equilibrium toward the inactive receptor state.
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 774   Edition : 3.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Onion with Another pathway.  

  ►  Pathway with its reference as follows :-
  • Onion having active constituent quercetin which act as antihistamine effect . --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL --
  • http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal
    Ref :-   Book : Martindale    Page : 621   Edition : 38.  

    ►    Plasma Half-life :   Min value :-   2 hours,    Max value :-   43 hours.  
    Ref :-   Book : Martindale    Page : 621   Edition : 38.  

    ►    Peak Plasma Concentration :   Min value :-   2.5 hours,    Max value :-   6 hours.  
    Ref :-   Book : Martindale    Page : 621   Edition : 38.