Chlorpromazine is a Medicine belongs to Antipsychotic group whose information about Brand can be referenced from   Book : Martindale    Page : 1053   Edition : 38,

  ►   Brandname : Thorazine,Largactil; Cain; Emetil

  ►  Strength : Tablet with 10  Mg, Tablet with 25  Mg, Tablet with 50  Mg, Tablet with 100  Mg, Tablet with 200  Mg, Suppository with 100  Mg, Injection with 25  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 519   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM, IV, rectal,
Reference :-   Book : Martindale    Page : 1045   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Psychiatric disorders Oral 25 mg
2 Psychiatric disorders IM 25 50 mg Injection t.i.d/q.i.d
3 Psychiatric disorders rectal 100 mg Suppository
4 Nausea and vomiting Oral 10 25 mg every 4 to 6 hours
5 Nausea and vomiting IM 25 mg Injection
6 Intractable hiccups Oral 25 50 mg t.i.d/q.i.d dose: for 2 to 3 days

Ref :-  Book : Martindale    Page : 1045   Edition : 38, Martindale    Page : 1046   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 psychiatric indication 6 Year 12 Year Oral 10 mg t.i.d.

Ref :- Book : Martindale    Page : 1046   Edition : 38,
►  Side Effect : dry mouth, constipation, difficulty in micturition, Blurred Vision, mydriasis, tachycardia, ECG changes, hypotension, delirium, agitation, hypersensitivity reactions, Urticaria, exfoliative dermatitis, erythema multiforme, contact sensitivity, photosensitivity reactions, haemolytic anaemia, aplastic anaemia, thrombocytopenic purpura, eosinophilia, fatal agranulocytosis, cardiac arrhythmia, catatonic-like states, insomnia, drowsiness, nightmares, Depression, Miosis, EEG changes, convulsion, nasal congestion, impotence, pigmentary retinopathy, minor abnormalities in liver function tests, inhibition of ejaculation, priapism, amenorrhoea, galactorrhoea, Gynaecomastia, hyperprolactinaemia, Hyperglycaemia, hypercholesterolaemia, hyperprolactinaemia, asphyxia,
Ref :-   Book : Martindale    Page : 1072   Edition : 37, Martindale    Page : 1047   Edition : 38,

►  Drug Interaction : Drug interaction of Chlorpromazine is with Alcohol, General anaesthetics , Hypnotic , Anxiolytics, Opoids, Quinolones, , antiarrhythmic agent, Antipsychotic , Non Sedating Antihistamines, antimalarial , Diuretic Agents , Tricyclic antidepressant , Corticosteroid , Oral Contraceptive, Thiazide Diuretics , Thyroid hormone , Angiotensin converting enzyme inhibitor, Alcohol, FLUOROQUINOLONES , Monoamine Oxidase Inhibitor, Serotonin Reuptake Inhibitor, Tricyclic antidepressant , Alcohol,  Cisapride , Tetracycline ,
Ref :-   Book : Martindale    Page : 1051   Edition : 38, Martindale    Page : 1052   Edition : 38, Martindale    Page : 470,503   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Symptoms of CNS depression may be enhanced by other drugs with CNS-depressant properties including alcohol, general anaesthetics, hypnotics, anxiolytics, and opioids. When given with other drugs that produce orthostatic hypotension, There is an increased risk of arrhythmias when antipsychotics are used with drugs that prolong the QT interval, including certain antiarrhythmics, other antipsychotics, some non-sedating antihistamines, antimalarials, and cisapride; use with diuretics that cause electrolyte imbalance (particularly hypokalaemia) may also have the same effect. There is also an increased risk of arrhythmias when tricyclic antidepressants are used with antipsychotics that prolong the QT interval.,
Ref :-   Book : Martindale    Page : 1076   Edition : 37,


►  Contraindication : bone marrow suppression, CNS depression, coma, phaeochromocytoma, prolactin dependent tumors, subcutaneous injection, hepatic impairment, renal impairment, cardiovascular or cerebrovascular disorder, open angle glaucoma, Parkinson’s disease, Diabetes mellitus, Hypothyroidism, Myasthenia gravis,
Ref :-   Book : Martindale    Page : 474, 502,503   Edition : 37, Martindale    Page : 1045   Edition : 38, Martindale    Page : 1050   Edition : 38,
  ►  Mechanism of Action :   Antagonize mesolimbic, and possibly mesocortical, D2 receptors,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 204   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Poppy seed with Another pathway,

  ►  Pathway with its reference as follows :-
  • antipsychotic effect . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan.,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- AGNUS CASTUS I.E. NIRGANDHI with Nirgandhi interact with dopamine antagosit drug, EVENING PRIMROSE OIL with Potential risk of seizures , KAVA with Cause excessive drawsiness,

      ►  Reference :-
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf, https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,

    ►   Route of Elimination :   Hepatic (Metabolism), Renal, Biliary,
    Ref :-   Book : Martindale    Page : 1078   Edition : 37, Martindale    Page : 1053   Edition : 38,


    ►    Plasma Half-life :   Min value :-   30 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1053   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 1053   Edition : 38,