Chlorpropamide is a Medicine belongs to Antidiabetic group whose information about Brand can be referenced from   Book : Martindale    Page : 470   Edition : 38,

  ►   Brandname : Copamide,Diabinese; Chlorformin

  ►  Strength : Tablet with 100  mg, Tablet with 250  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 766   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Basic & Clinical pharmacology    Page : 766   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Diabetes mellitus Oral 250 mg Tablet single dose with breakfast.
2 Diabetes insipidus Oral 100 mg Tablet Dose : daily.

Ref :-  Book : Martindale    Page : 474   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Diabetes mellitus Oral 250 500 mg Tablet o.d.

Ref :- Book : Nelson's textbook of Pediatrics    Page : 1992   Edition : 19,
►  Side Effect : hyponatraemia, nausea, vomiting, anorexia, diarrhea, metallic taste, Skin rashes, photosensitivity, mild hypoglycaemia, hepatitis, cholestatic jaundice, leucopenia, thrombocytopenia, aplastic anaemia, agranulocytosis, Hemolytic anemia, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis,
Ref :-   Book : Martindale    Page : 474, 501-502   Edition : 37,

►  Drug Interaction : Drug interaction of Chlorpropamide is with Alcohol, Corticosteroid , Oral Contraceptive, Thiazide Diuretics , Thyroid hormone , Angiotensin converting enzyme inhibitor, Azole Antifungal, FLUOROQUINOLONES , Monoamine Oxidase Inhibitor, Serotonin Reuptake Inhibitor, Tricyclic antidepressant , Beta Blockers ,  cotrimoxazole, Sulfinpyrazone, Ranitidine , Disopyramide , Clarithromycin , Chloramphenicol , Heparin , Fluconazole , Cimetidine , Miconazole, Ketoconazole , Salicylic acid , Phenylbutazone, Azapropazone, Allopurinol , Rifampicin , Diazoxide , Chlorpromazine , aminoglutethimide , Adrenaline,
Ref :-   Book : Martindale    Page : 470,503   Edition : 38, Martindale    Page : 470, 503   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  A reduced hypoglycaemic effect, possibly requiring an increased dose of sulfonylurea, has been seen or might be expected on theoretical grounds with adrenaline, aminoglutethimide, chlorpromazine, corticosteroids, diazoxide, oral contraceptives, rifamycins, thiazide diuretics, and thyroid hormones. An increased hypoglycaemic effect has occurred or might be expected with ACE inhibitors, alcohol, allopurinol, some analgesics (notably azapropazone, phenylbutazone, and the salicylates), azole antifungals (fluconazole, ketoconazole, and miconazole), chloramphenicol, cimetidine, clofibrate and related compounds, coumarin anticoagulants, fluoroquinolones, heparin, MAOIs, octreotide (although this may also produce hyperglycaemia), ranitidine, sulfinpyrazone, sulfonamides (including co-trimoxazole), tetracyclines, and tricyclic antidepressants. Beta blockers may reduce the efficacy of sulfonylureas by impairing the release of insulin from the pancreas. ,
Ref :-   Book : Martindale    Page : 470,503   Edition : 38,


►  Contraindication : hepatic impairment, ketoacidosis, pregnancy, renal impairment, serious infection, trauma, Type 1 diabetes mellitus, condition associated with fluid retention,
Ref :-   Book : Martindale    Page : 470, 502   Edition : 38,
  ►  Mechanism of Action :   Inhibit the β-cell K+/ATP channel at the SUR1 subunit, thereby stimulating insulin release from pancreatic β-cells and increasing circulating insulin to levels sufficient to overcome insulin resistance.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 538   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Fenugreek seed with Another pathway,

  ►  Pathway with its reference as follows :-
  • Anti-diabetes effect . --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 474   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   35 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 474   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,