Chlorthalidone is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1335   Edition : 38,    Page :   Edition : ,

  ►   Brandname : Hythalton,Thalizide,Hygroton,Thalitone,CTD,Tazloc CT 40,Telma CT

  ►  Strength : Tablet with 25  mg, Tablet with 50  mg, Tablet with 100  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 269   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1335   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Hypertension Oral 25 mg Tablet Given either alone or with other antihypertensives.
2 Oedema Oral 25 50 mg Tablet Daily.
3 Diabetes insipidus Oral 100 mg Tablet b.d.

Ref :-  Book : Martindale    Page : 1335   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Hypertension Oral 0.3 mg/kg/day Tablet

Ref :- Book : Nelson's textbook of Pediatrics    Page : 1645   Edition : 19,
►  Side Effect : vertigo, headache, paraesthesia, xanthopsia, weakness, anorexia, nausea, cramping, diarrhea, constipation, cholecystitis, Pancreatitis, blood dyscrasias, photosensitivity, Skin rashes, extracellular volume depletion, hypotension, hypokalaemia, hyponatraemia, hypochloremia, metabolic alkalosis, hypomagnesemia, hypercalcaemia, hyperuricaemia, erectile dysfunction, decrease in glucose tolerance, latent diabetes mellitus, increase plasma level of cholesterol, increase plasma level of total cholesterol, increase plasma level of total triglycerides, increase plasma levels of LDL ,
Ref :-   Book : Goodman    Page : 689   Edition : 12, Martindale    Page : 689   Edition : 12,

►  Drug Interaction : Drug interaction of Chlorthalidone is with Anticoagulant , Uricosuric, sulfonylurea antidiabetic , Digitalis Antibody , , Loop Diuretics ,  Vitamin D, Amphotericin B , Insulin , Diazoxide , digitalis, Lithium carbonate ,
Ref :-   Book : Goodman    Page : 689   Edition : 12,


  ►    Mechanism of Drug Drug Interaction :  Thiazide diuretics may diminish the effects of anticoagulants, uricosuric agents used to treat gout, sulfonylureas, and insulin and may increase the effects of anesthetics, diazoxide, digitalis glycosides, lithium, loop diuretics, and vitamin D. The effectiveness of thiazide diuretics may be reduced by NSAIDs, nonselective or selective COX-2 inhibitors, and bile acid sequestrants (reduced absorption of thiazides). Amphotericin B and corticosteroids increase the risk of hypokalemia induced by thiazide diuretics. ,
Ref :-   Book : Goodman    Page : 689   Edition : 12,


►  Contraindication : hepatic impairment, hepatic cirrhosis, Salt intake, Large dose of thiazides, Addison’s disease , renal impairment,
Ref :-   Book : Martindale    Page : 1369,1440   Edition : 37,
  ►  Mechanism of Action :   Decreases NaCl reabsorption in the distal convoluted tubule,
Ref :-   Book : Basic & Clinical pharmacology    Page : 222   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Watermelon with Another pathway, Cucumber with Another pathway, muskmelon with Another pathway,

  ►  Pathway with its reference as follows :-
  • Potassium depleting diuretic --- (Cemaluk, C. (2015). Comparative Investigation of the Antibacterial and Antifungal Potentials of the Extracts of Watermelon (Citrullus lanatus) Rind and Seed. EJMP, 9(4), pp.1-7. )
  • Potassium depleting diuretic --- (23. Maheshwari, R. (2014). Invigorating Efficacy of Cucumis Sativas for Healthcare & Radiance. international journal of chemistry & pharmacuticle science, 2(3). )
  • Potassium depleting diuretic --- (24. Milind, p. (2011). muskmelon is eat muskmelon. international research journal of pharmacy, 2(8), pp.52-57 )

  •   ►  URL -- http://sciencedomain.org/abstract/10142, http://www.pharmaresearchlibrary.com/wp-content/uploads/2014/04/IJCPS20011.pdf, http://www.irjponline.com/admin/php/uploads/vol-2_issue-8/10.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- POTASSIUM with Decrease in Nutrient Level, MAGNESIUM with Decrease in Nutrient Level, FOLIC ACID with Decrease in Nutrient Level,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- ALOE VERA with Cause hypokalemia with potassium depleting diuretic .,

      ►  Reference :-
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 1335   Edition : 38,


    ►    Plasma Half-life :   Min value :-   40 hours,    Max value :-   60 hours,
    Ref :-   Book : Martindale    Page : 1369   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,