Cholecalciferol is a Medicine belongs to Nutritional agent and vitamin group whose information about Brand can be referenced from   Book : Martindale    Page : 2118   Edition : 38,    Page :   Edition : ,

  ►   Brandname : Vitamin D3,Delta D; AT10; Alfacan; Alfa caps; Advance D; Baby Drops,Calcirol Powder,San D,Shelcal,Shelcal HD,Tayo,Tayo 60K

  ►  Strength : Numerous forms with 400-50000  IU per unit,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 786   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM, IV,
Reference :-   Book : Martindale    Page : 2114   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Simple nutritional deficiencies Oral 10 micrograms daily.
2 Simple nutritional deficiencies IM 10 micrograms Injection Daily.
3 Simple nutritional deficiencies IM 10 micrograms Injection Daily.
4 Malabsorption states Oral Up to 1 mg Daily.
5 Liver disease Oral Up to 1 mg Daily.
6 Liver disease Oral Up to 1 mg Daily.
7 Hypocalcaemia Oral Up to 5 mg Due to Hypoparathyroidism. Dose: Daily.

Ref :-  Book : Martindale    Page : 2114   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Hyperphosphataemia, hypercalcaemia, hypercalciuria, ectopic calcification, anorexia, lassitude, nausea, vomiting, constipation, diarrhea, polyuria, nocturia, sweating, headache, thirst, Somnolence, vertigo, Skin irritation, Contact dermatitis,
Ref :-   Book : Martindale    Page : 2117   Edition : 38,

►  Drug Interaction : Drug interaction of Cholecalciferol is with Thiazide Diuretics , , , Corticosteroid , ,  Carbamazapine , Phenobarbital , Phenytoin , Primidone , Rifampicin , Isoniazid , Ketoconazole ,
Ref :-   Book : Martindale    Page : 2117   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  There is an increased risk of hypercalcaemia if vitamin D is given with thiazide diuretics, calcium, or phosphate. Plasma-calcium concentrations should be monitored in such situations. Some antiepileptics may increase vitamin D requirements (e.g. carbamazepine, phenobarbital, phenytoin, and primidone). Rifampicin and isoniazid may reduce the effectiveness of vitamin D. Corticosteroids may counteract the effect of vitamin D. Ketoconazole may inhibit the metabolism of paricalcitol and these drugs should be used with caution together; care should be taken when using paricalcitol with other potent inhibitors of the cytochrome P450 isoenzyme CYP3A4.,
Ref :-   Book : Martindale    Page : 2117,2118   Edition : 38,


►  Contraindication : hypercalcaemia, Infant, renal impairment, Cardiac disease,
Ref :-   Book : Martindale    Page : 2117   Edition : 38,
  ►  Mechanism of Action :   Regulate gene transcription via the vitamin D receptor. ,
Ref :-   Book : Basic & Clinical pharmacology    Page : 785   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- with Another pathway,

  ►  Pathway with its reference as follows :-
  • Nutrient Supplement --- (Gopalan, C. (2012). Nutritive value of Indian foods. National Institute of Nutrition ,ICMR.: Hyderabad 500007,INDIA. )

  •   ►  URL -- http://www.eeb.cornell.edu/biogeo/nanc/Food_Feed/table%201%20gopalan%20et%20al%201989.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Biliary, Fecal, Renal,
    Ref :-   Book : Martindale    Page : 2118   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,

    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,