Cholestyramine is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1347   Edition : 38,

  ►   Brandname : Locholest,Prevalite,Questran; Colestyr; Lipocol; Vasosan

  ►  Strength : Oral solution with   , Powder with 4  gm,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1347   Edition : 38, Basic & Clinical pharmacology    Page : 633   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1346   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Pruritus Oral 4 8 gm daily.
2 Hyperlipidaemia Oral 12 24 gm Daily, given either as a single dose or in up to 4 divided doses.
3 Diarrhea Oral 12 24 gm Daily, given either as a single dose or in up to 4 divided doses.

Ref :-  Book : Martindale    Page : 1346   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Hypercholesterolaemias 6 Year 12 Year Oral 4 gm o.d.
2 Pruritus 1 Month 1 Year Oral 1 gm o.d.
3 Diarrhea 1 Month 1 Year Oral 1 gm
4 Diarrhea 6 Year 12 Year Oral 4 gm o.d.
5 Diarrhea 12 Year 18 Year Oral 4 8 gm o.d.
6 Pruritus 6 Year 12 Year Oral 4 gm o.d.
7 Pruritus 12 Year 18 Year Oral 4 8 gm o.d.
8 Pruritus 1 Year 6 Year Oral 2 gm o.d.
9 Diarrhea 1 Year 6 Year Oral 2 gm o.d.

Ref :- Book : Martindale    Page : 1346   Edition : 38,
►  Side Effect : constipation, abdominal discomfort, abdominal pain, heartburn, Flatulence, nausea, vomiting, diarrhea, Skin rashes, pruritus of the tongue, pruritus of the skin, pruritus of the perianal region,
Ref :-   Book : Martindale    Page : 1346   Edition : 38,

►  Drug Interaction : Drug interaction of Cholestyramine is with Thiazide Diuretics , Barbiturates , Thyroid hormone ,  Propranolol , Digoxin , Loperamide , Phenylbutazone, oestrogen, Progestogen, Warfarin ,
Ref :-   Book : Martindale    Page : 1347   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Colestyramine may delay or reduce the absorption of other drugs, particularly acidic drugs. Enterohepatic circulation may be reduced. Delayed or reduced absorption of thiazide diuretics, propranolol, digoxin and related glycosides, loperamide, phenylbutazone, barbiturates, oestrogens, progestogens, thyroid hormones, warfarin, and some antibacterials, has either been reported or may be expected. ,
Ref :-   Book : Martindale    Page : 1347   Edition : 38,


►  Contraindication : complete biliary obstruction,
Ref :-   Book : Martindale    Page : 1346   Edition : 38,
  ►  Mechanism of Action :   Colestyramine is a bile-acid binding resin and lipid regulating drug. Colestyramine is not absorbed from the gastrointestinal tract and binds with bile acids in the intestine to form an insoluble complex that is excreted in the faeces. The normal reabsorption of bile acids is thus prevented and this leads to an increased oxidation of cholesterol to bile acids to replace those partially removed from the enterohepatic circulation, and an increased synthesis of low-density lipoprotein (LDL)-cholesterol receptors on hepatocytes. The overall effect is a reduction of total plasma-cholesterol concentration, mainly by lowering LDL-cholesterol; this may be accompanied by moderate increases in plasma triglyceride and high-density lipoprotein (HDL)-cholesterol concentrations.,
Ref :-   Book : Martindale    Page : 1346   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Garlic with Another pathway,

  ►  Pathway with its reference as follows :-
  • Lipid Lowering Effect --- (18. PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- IRON with Dietary Substance is Drug Inhibitor, VITAMIN A with Decrease in Nutrient Level, VITAMIN D with Decrease in Nutrient Level, VITAMIN E with Decrease in Nutrient Level, VITAMIN K with Decrease in Nutrient Level, BETACAROTENE with Decrease in Nutrient Level,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20, http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- CALCIUM with Increases urinary calcium excretion .,

      ►  Reference :-
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,

    ►   Route of Elimination :   Fecal,
    Ref :-   Book : Martindale    Page : 1346   Edition : 38,


    ►    Plasma Half-life :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,


    ►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,