Choline Theophyllinate is a Medicine belongs to bronchodilator group whose information about Brand can be referenced from   Book : Martindale    Page : 1207   Edition : 38  

  ►   Brandname : Choledyl; Airomol; Alkarex
  ►  Strength : Tablet with .  Solution with

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1207   Edition : 38  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 1207   Edition : 38  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Reversible airways obstruction Oral 800 mg Daily in 4 divided doses.

Ref :-  Book : Martindale    Page : 1207   Edition : 38  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 From 10 Year Oral 100 200 mg

Ref :- Book : Martindale    Page : 1207   Edition : 38  
►  Side Effect : Nausea, Vomiting, Abdominal pain, Gastrointestinal disturbance, Insomnia, Headache, Anxiety, irritability, Restlessness, Tremor, palpitations, Overdosage may also lead to agitation, diuresis and repeated vomiting
Ref :-   Book : Martindale    Page : 1207,1231   Edition : 38.  

►  Drug Interaction : Drug interaction of Choline Theophyllinate is with Macrolide, Quinolones, Oral Contraceptive, Beta 2 Agonist, Competitive neuromuscular blockers, Corticosteroid , , ,  Allopurinol , Cimetidine , Disulfiram, Tiabendazole, Viloxazine, Phenytoin , Ritonavir, Rifampicin , Sulfinpyrazone, Halothane , Ketamine , Fluvoxamine
Ref :-   Book : Martindale    Page : 1207,1233   Edition : 38.  

  ►    Mechanism of Drug Drug Interaction :  Choline Theophyllinate clearance may be reduced by interaction with other drugs including allopurinol, some antiarrhythmics, cimetidine, disulfiram, fluvoxamine, interferon alfa, macrolide antibacterials and quinolones, oral contraceptives, tiabendazole, and viloxazine, and the dose of Choline Theophyllinate may need to be reduced. Phenytoin and some other antiepileptics, ritonavir, rifampicin, and sulfinpyrazone may increase Choline Theophyllinate clearance, and require an increase in dose or dosing frequency of Choline Theophyllinate. Xanthines can potentiate hypokalaemia caused by hypoxia or associated with the use of beta2-adrenoceptor stimulants (beta2 agonists), corticosteroids, and diuretics. There is a risk of synergistic toxicity Choline Theophyllinate if is given with halothane or ketamine, and it may antagonise the effects of adenosine and of competitive neuromuscular blockers; lithium elimination may be enhanced with a consequent loss of effect.
Ref :-   Book : Martindale    Page : 1233,1257   Edition : 37.  

►  Contraindication : Peptic ulceration, Porphyria, Hyperthyroidism, Epilepsy, Heart failure, Other cardiovascular disease, Hepatic dysfunction, Acute febrile illness
Ref :-   Book : Martindale    Page : 1207,1233   Edition : 38.  
  ►  Mechanism of Action :   It is a xanthine and relaxes bronchial smooth muscle, relieves bronchospasm, and has a stimulant effect on respiration. It stimulates the myocardium and CNS, decreases peripheral resistance and venous pressure, and causes diuresis. It is still not clear how theophylline exerts these effects. Inhibition of phosphodiesterase with a resulting increase in intracellular cyclic adenosine monophosphate (cyclic AMP) occurs, and may play a role. Other proposed mechanisms of action include adenosine receptor antagonism, prostaglandin antagonism, and effects on intracellular calcium. In addition, theophylline may also have an anti-inflammatory effect.
Ref :-   Book : Martindale    Page : 1207,1229   Edition : 38.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- Onion with Another pathway.  

  ►  Pathway with its reference as follows :-
  • work as bronchodilator --- ( Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL --
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  • DIETARY Substance Interactions

    ​   ► This Medicine interact with :- NA

    ContraIndication DIETARY Substance

    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   NA

    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA