Cidofovir is a Medicine belongs to Antiviral group whose information about Brand can be referenced from   Book : Martindale    Page : 970   Edition : 38,

  ►   Brandname : Vistide

  ►  Strength : Injection with 375  mg/vial,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 888   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV infusion, intravitreal injection,
Reference :-   Book : Martindale    Page : 970   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 CMV retinitis IV infusion 5 mg/kg Injection intravenous infusion over 1 hour once a week for 2 consecutive weeks, then once every 2 weeks for maintenance. Probenecid 2 g is given orally 3 hours before each dose of cidofovir and further 1- g doses of probenecid at 2 and 8 hours after completion of the infusion.

Ref :-  Book : Martindale    Page : 970   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : nephrotoxicity, metabolic acidosis, Liver dysfunction, Pancreatitis, nausea, vomiting, fever, asthenia, Skin rashes, dyspnoea, alopecia, ocular hypotony, iritis, uveitis, proximal tubule injury, Reversible neutropenia, diarrhoea, renal wasting syndrome (including Fanconi’s syndrome),
Ref :-   Book : Martindale    Page : 957   Edition : 37, Martindale    Page : 970   Edition : 38,

►  Drug Interaction : Drug interaction of Cidofovir is with Non Sterodial Anti- Inflammatory Drugs , Aminoglycoside antibiotic ,  Amphotericin B , Foscarnet , Pentamidine , Vancomycin ,
Ref :-   Book : Martindale    Page : 971   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Additive nephrotoxicity may occur if cidofovir is used with other nephrotoxic drugs such as aminoglycosides, amphotericin B, foscarnet, intravenous pentamidine, vancomycin, or NSAIDs.,
Ref :-   Book : Martindale    Page : 971   Edition : 38,


►  Contraindication : Pregnancy, renal impairment, Hypersensitivity, It should not be given with Tenofovir disoproxil fumarate due to the increased risk of fanconi syndrome.,
Ref :-   Book : Martindale    Page : 970   Edition : 38,
  ►  Mechanism of Action :   Cidofovir is phosphorylated by cellular enzymes and then inhibits CMV DNA polymerase. ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 670   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Green tea with Another pathway,

  ►  Pathway with its reference as follows :-
  • Caffeic acid have Anti viral effect --- ( Lee, H., Lee, Y., Youn, H., Lee, D., Kwak, J., & Seong, B. et al. (2011). Anti-influenza virus activity of green tea by-products in vitro and efficacy against influenza virus infection in chickens. Poultry Science, 91(1), 66-73 )

  •   ►  URL -- http://ps.oxfordjournals.org/content/91/1/66.full,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 971   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   2.2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 971   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA