Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No	Ailment	Route	Dose Min	Dose Max	Unit	Dosage Form	Frequency	Additional Info
1	Acid aspiration syndrome during general anaesthesia	Oral	400		mg		q.i.d.	With meals and at bedtime.
2	Zollinger-ellison syndrome	Oral	300		mg		q.i.d.
3	Stress ulcer	Oral	200	400	mg			Every 4 to 6 hours.
4	Acid aspiration syndrome	Oral	400		mg			Dose: 90 to 120 minutes before the induction of anaesthesia or at the start of labour.
5	Prophylaxis of nocturnal heartburn.	Oral	100		mg			At night.
6	Pancreatic insufficiency	Oral	800	1600	mg			Daily in 4 divided doses, 60 to 90 minutes before meals.
7	Benign duodenal ulceration	Oral	800		mg		h.s.	Daily single dose for at least 4 weeks.
8	Benign gastric ulceration	Oral	800		mg		h.s.	Daily single dose for at least 6 weeks.
9	Benign gastric ulceration	Oral	400		mg		b.d.
10	Benign duodenal ulceration	Oral	400		mg		b.d.
11	Gastroesophageal reflux disease	Oral	800		mg		b.d.	For 4 to 12 weeks.
12	Non-ulcer dyspepsia	Oral	up to 800		mg			Daily in divided dose.
13	Short bowel syndrome	Oral	400		mg		b.d.
14	Zollinger-ellison syndrome	Oral	400		mg		q.i.d.

Adult Dose

S.No	Ailment	Route	Dose Min	Dose Max	Unit	Dosage Form	Frequency	Additional Info
1	Acid aspiration syndrome during general anaesthesia	Oral	400		mg		q.i.d.	With meals and at bedtime.
2	Zollinger-ellison syndrome	Oral	300		mg		q.i.d.
3	Stress ulcer	Oral	200	400	mg			Every 4 to 6 hours.
4	Acid aspiration syndrome	Oral	400		mg			Dose: 90 to 120 minutes before the induction of anaesthesia or at the start of labour.
5	Prophylaxis of nocturnal heartburn.	Oral	100		mg			At night.
6	Pancreatic insufficiency	Oral	800	1600	mg			Daily in 4 divided doses, 60 to 90 minutes before meals.
7	Benign duodenal ulceration	Oral	800		mg		h.s.	Daily single dose for at least 4 weeks.
8	Benign gastric ulceration	Oral	800		mg		h.s.	Daily single dose for at least 6 weeks.
9	Benign gastric ulceration	Oral	400		mg		b.d.
10	Benign duodenal ulceration	Oral	400		mg		b.d.
11	Gastroesophageal reflux disease	Oral	800		mg		b.d.	For 4 to 12 weeks.
12	Non-ulcer dyspepsia	Oral	up to 800		mg			Daily in divided dose.
13	Short bowel syndrome	Oral	400		mg		b.d.
14	Zollinger-ellison syndrome	Oral	400		mg		q.i.d.

Ref :-  Book : Martindale    Page : 1827   Edition : 38  

Pediatric Dose

Ref :- Book : Nelson's textbook of Pediatrics    Page : 815   Edition : 19  

Precaution :- If a Patient is using 'Cimetidine' drug in  Gynecomastia  disease, then Please not be used .

Precaution :- If a Patient is using 'Cimetidine' drug in PEPTIC ULCER DISEASE disease, then Please use with caution with warfarin   if he ever suffered from mitral stenosis disease.
Precaution :- If a Patient is using 'Cimetidine' drug in PEPTIC ULCER DISEASE disease, then Please use with caution with phenytoin   if he ever suffered from Epilapsy disease.
Precaution :- If a Patient is using 'Cimetidine' drug in  PEPTIC ULCER DISEASE  disease, then Please use with caution in the presence of thrombocytopenia .

►  Side Effect : Diarrhea, Gastrointestinal disturbance, Gynaecomastia, impotence, Dizziness, Tiredness, Headache, Rashes, Arthralgia, Myalgia
Ref :-   Book : Martindale    Page : 1828   Edition : 38.  
►  Drug Interaction : Drug interaction of Cimetidine is with , , bigunide/antidiabetic drug , opioid analgesics,  Lidocaine , Dasatinib, Ketoconazole , Itraconazole , Posaconazole , Dofetilide , Procainamide , Phenytoin , Carbamazapine , Moclobemide , Nifedipine , Carmustine , Sildenafil , Theophylline , Amitriptyline , Warfarin , Zalcitabine, Zolmitriptan
Ref :-   Book : Martindale    Page : 1830   Edition : 38.  

Drug interaction

Drug Interaction : Drug interaction of Cimetidine is with , , bigunide/antidiabetic drug , opioid analgesics,  Lidocaine , Dasatinib, Ketoconazole , Itraconazole , Posaconazole , Dofetilide , Procainamide , Phenytoin , Carbamazapine , Moclobemide , Nifedipine , Carmustine , Sildenafil , Theophylline , Amitriptyline , Warfarin , Zalcitabine, Zolmitriptan

Book : Martindale    Page : 1830   Edition : 38.  

  ►    Mechanism of Drug Drug Interaction :  Cimetidine and other H2-antagonists can reduce the absorption of drugs such as dasatinib, ketoconazole, and possibly itraconazole, whose absorption is dependent on an acid gastric pH. Cimetidine may inhibit the hepatic metabolism of many drugs by binding to cytochrome P450 isoenzymes. Antiepileptics such as phenytoin, carbamazepine, Biguanide antidiabetics , Lidocaine , Nifedipine, opioid analgesics, procainamide , theophylline , tricyclic antidepressants such as amitriptyline , Warfarin and other oral anticoagulants, zalcitabine , zolmitriptan , Combinations of these drugs and cimetidine should be avoided or used with caution, with monitoring of effects or plasma-drug concentrations and reductions in dosage as appropriate.
Ref :-   Book : Martindale    Page : 1830   Edition : 38.  

Mechanism of Drug

Mechanism of Drug Drug Interaction : Cimetidine and other H2-antagonists can reduce the absorption of drugs such as dasatinib, ketoconazole, and possibly itraconazole, whose absorption is dependent on an acid gastric pH. Cimetidine may inhibit the hepatic metabolism of many drugs by binding to cytochrome P450 isoenzymes. Antiepileptics such as phenytoin, carbamazepine, Biguanide antidiabetics , Lidocaine , Nifedipine, opioid analgesics, procainamide , theophylline , tricyclic antidepressants such as amitriptyline , Warfarin and other oral anticoagulants, zalcitabine , zolmitriptan , Combinations of these drugs and cimetidine should be avoided or used with caution, with monitoring of effects or plasma-drug concentrations and reductions in dosage as appropriate.

Book : Martindale    Page : 1830   Edition : 38.  

►  Contraindication : Cardiac arrhythmias, Cardiac arrest, Transient hypotension
Ref :-   Book : Martindale    Page : 1828   Edition : 38.  

  ►  Mechanism of Action :   Decrease acid secretion by inhibiting histamine binding to H2 receptors on parietal cells
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 818   Edition : 3.  

►   Route of Elimination :   Renal
Ref :-   Book : Martindale    Page : 1831   Edition : 38.  
►    Plasma Half-life :   Min value :-   2 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1831   Edition : 38.  
►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1831   Edition : 38.