Cimetidine is a Medicine belongs to Gastrointestinal drug group whose information about Brand can be referenced from   Book : Martindale    Page : 1831   Edition : 38,

  ►   Brandname : Cimet,Dyspamet,Galenamet,Tagamet,Zita; Dyspamet; Cimetin; Cimebeta; A Li Wei

  ►  Strength : Tablet with 200  mg, Tablet with 300  mg, Tablet with 400  mg, Tablet with 800  mg, Liquid with 300/5  mg/ml, Injection with 300/2  mg/ml, Injection with 300/50  mg/ml, Suspension with   , Solution with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 1111   Edition : 12, Martindale    Page : 1831   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV, IM,
Reference :-   Book : Martindale    Page : 1827   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Acid aspiration syndrome during general anaesthesia Oral 400 mg q.i.d. With meals and at bedtime.
2 Zollinger-ellison syndrome Oral 300 mg q.i.d.
3 Stress ulcer Oral 200 400 mg Every 4 to 6 hours.
4 Acid aspiration syndrome Oral 400 mg Dose: 90 to 120 minutes before the induction of anaesthesia or at the start of labour.
5 Prophylaxis of nocturnal heartburn. Oral 100 mg At night.
6 Pancreatic insufficiency Oral 800 1600 mg Daily in 4 divided doses, 60 to 90 minutes before meals.
7 Benign duodenal ulceration Oral 800 mg h.s. Daily single dose for at least 4 weeks.
8 Benign gastric ulceration Oral 800 mg h.s. Daily single dose for at least 6 weeks.
9 Benign gastric ulceration Oral 400 mg b.d.
10 Benign duodenal ulceration Oral 400 mg b.d.
11 Gastroesophageal reflux disease Oral 800 mg b.d. For 4 to 12 weeks.
12 Non-ulcer dyspepsia Oral up to 800 mg Daily in divided dose.
13 Short bowel syndrome Oral 400 mg b.d.
14 Zollinger-ellison syndrome Oral 400 mg q.i.d.

Ref :-  Book : Martindale    Page : 1827   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 UTICARIA Oral 10 20 mg/kg/day
2 UTICARIA Oral 20 40 mg/kg/day
3 Angioedema Oral 10 20 mg/kg/day
4 Angioedema Oral 20 40 mg/kg/day

Ref :- Book : Nelson's textbook of Pediatrics    Page : 815   Edition : 19,
Precaution :- If a Patient is using 'Cimetidine' drug in  Gynecomastia  disease, then Please not be used .

Precaution :- If a Patient is using 'Cimetidine' drug in PEPTIC ULCER DISEASE disease, then Please use with caution with warfarin   if he ever suffered from mitral stenosis disease.
Precaution :- If a Patient is using 'Cimetidine' drug in PEPTIC ULCER DISEASE disease, then Please use with caution with phenytoin   if he ever suffered from Epilapsy disease.
Precaution :- If a Patient is using 'Cimetidine' drug in  PEPTIC ULCER DISEASE  disease, then Please use with caution in the presence of thrombocytopenia .

►  Side Effect : diarrhea, gastrointestinal disturbance, Gynaecomastia, impotence, Dizziness, Tiredness, headache, Rashes, arthralgia, myalgia, ,
Ref :-   Book : Martindale    Page : 1828   Edition : 38,

►  Drug Interaction : Drug interaction of Cimetidine is with , , bigunide/antidiabetic drug , opioid analgesics,  Lidocaine , Dasatinib, Ketoconazole , Itraconazole , Posaconazole , Dofetilide , Procainamide , Phenytoin , Carbamazapine , Moclobemide , Nifedipine , Carmustine , Sildenafil , Theophylline , Amitriptyline , Warfarin , Zalcitabine, Zolmitriptan ,
Ref :-   Book : Martindale    Page : 1830   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Cimetidine and other H2-antagonists can reduce the absorption of drugs such as dasatinib, ketoconazole, and possibly itraconazole, whose absorption is dependent on an acid gastric pH. Cimetidine may inhibit the hepatic metabolism of many drugs by binding to cytochrome P450 isoenzymes. Antiepileptics such as phenytoin, carbamazepine, Biguanide antidiabetics , Lidocaine , Nifedipine, opioid analgesics, procainamide , theophylline , tricyclic antidepressants such as amitriptyline , Warfarin and other oral anticoagulants, zalcitabine , zolmitriptan , Combinations of these drugs and cimetidine should be avoided or used with caution, with monitoring of effects or plasma-drug concentrations and reductions in dosage as appropriate. ,
Ref :-   Book : Martindale    Page : 1830   Edition : 38,


►  Contraindication : Cardiac arrhythmias, cardiac arrest, Transient hypotension,
Ref :-   Book : Martindale    Page : 1828   Edition : 38,
  ►  Mechanism of Action :   Decrease acid secretion by inhibiting histamine binding to H2 receptors on parietal cells,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 818   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- with Another pathway,

  ►  Pathway with its reference as follows :-
  • Menthol have Antacid effect --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 1831   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1831   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1831   Edition : 38,